ID A0A3Q0SQX4_AMPCI Unreviewed; 324 AA.
AC A0A3Q0SQX4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=protein acetyllysine N-acetyltransferase {ECO:0000256|ARBA:ARBA00012928};
DE EC=2.3.1.286 {ECO:0000256|ARBA:ARBA00012928};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000022610.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000022610.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sirtuin family. Class IV subfamily.
CC {ECO:0000256|ARBA:ARBA00038170}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00236}.
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DR AlphaFoldDB; A0A3Q0SQX4; -.
DR STRING; 61819.ENSACIP00000022610; -.
DR Ensembl; ENSACIT00000023212.1; ENSACIP00000022610.1; ENSACIG00000017596.1.
DR GeneTree; ENSGT00940000160088; -.
DR OMA; EQCKKCR; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR003000; Sirtuin.
DR InterPro; IPR026590; Ssirtuin_cat_dom.
DR PANTHER; PTHR11085; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR11085:SF13; NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-6; 1.
DR Pfam; PF02146; SIR2; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR PROSITE; PS50305; SIRTUIN; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 27..245
FT /note="Deacetylase sirtuin-type"
FT /evidence="ECO:0000259|PROSITE:PS50305"
FT REGION 288..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 324 AA; 35849 MW; 112E1A0A61903C75 CRC64;
MSVNYAAGLS PYANKGVCGL PEHFDSPEEL KAKVEALAQL IKESQYLVVH SGAGISTSAG
IPDFRGPKGV WTLEEKGESP HFDTTFEDAR PSLTHMALLG LQRAGYLKYL ISQNVDGLHV
RSGFPRDMLS ELHGNMFVEE CEKCGRQYVR EKVIGVMGLK PTGRYCEVVR SRGLRSCRRA
DLALTLGTSL QIKPSGDLPL LTKRKGGKLA IVNLQSTKHD KHAHLRIHGY VDEVMKQLME
LLGLEIPKWD GPTVCESSTT TSEITTDVKP PCVVTAKEKV EKDLVKEDRK REAAQLTNDG
SVKEETVSVK RERADLPVEI NEEK
//
