ID   A0A3Q0SSW5_AMPCI        Unreviewed;      1050 AA.
AC   A0A3Q0SSW5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=SLIT-ROBO Rho GTPase activating protein 3 {ECO:0000313|Ensembl:ENSACIP00000026546.1};
GN   Name=SRGAP3 {ECO:0000313|Ensembl:ENSACIP00000026546.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000026546.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000026546.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   AlphaFoldDB; A0A3Q0SSW5; -.
DR   Ensembl; ENSACIT00000027239.1; ENSACIP00000026546.1; ENSACIG00000020195.1.
DR   GeneTree; ENSGT00950000182824; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04383; RhoGAP_srGAP; 1.
DR   CDD; cd11955; SH3_srGAP1-3; 1.
DR   Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR   Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR027267; AH/BAR_dom_sf.
DR   InterPro; IPR031160; F_BAR.
DR   InterPro; IPR001060; FCH_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   InterPro; IPR035648; srGAP1/2/3_SH3.
DR   PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR   PANTHER; PTHR14166:SF8; SLIT-ROBO RHO GTPASE-ACTIVATING PROTEIN 3; 1.
DR   Pfam; PF00611; FCH; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00055; FCH; 1.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR   SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS51741; F_BAR; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW   ProRule:PRU01077};
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          1..284
FT                   /note="F-BAR"
FT                   /evidence="ECO:0000259|PROSITE:PS51741"
FT   DOMAIN          458..642
FT                   /note="Rho-GAP"
FT                   /evidence="ECO:0000259|PROSITE:PS50238"
FT   DOMAIN          690..749
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          664..687
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          758..874
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          959..1050
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          329..356
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        668..687
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        758..773
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        962..976
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1001..1050
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1050 AA;  118771 MW;  9D6BCD7AFCAB2F0C CRC64;
     TFIRNQLVEQ FKCLEQQSES RIQLLQDLQE FFRRKAEIEL EYSRSLEKLA ERFSSKIRNQ
     HLLSTVNCWY LLLSQTRRES RDHATLSDIY TNNVIVRLAQ ISEDVIRLFK KSKDIGIQMH
     EELVKVTNEL YTVMKTYHMY HTESTSAESK LKDAEKQEEK QFSKSGDLNV NLLRHEDRQS
     RRSSVRKIEK MKEKRQAKYS ENKLKCTKAR NDYLLNLAAT NAVVAKYYIH DVSDMIDCCD
     LGYHASLARA LRTYLSAEYN LETSRHEGLD IIENAVDNLD SRSDKHKIMD MHNQVFCPPM
     RFEYLPHMGD EVCQVSAQQP VQTELLMRYH QLQSRLATLK IENEEVRKTL DATMQTLQDM
     LTVEDFDVSD AFQHSRSTES IKSVASETYM SKLNIAKRRA NQQETEMFYF SKFKEYLNGS
     NLIIKLQAKH DLLKQTLGEG ERAECGTTSV SCMCTHFLSF QDSGQPIPLV VESCIRYINL
     YGLQQQGIFR VPGSQVEVND IKNSFERGED PLIDDQNEHD INSVAGVLKL YFRGLENPLF
     PKERFLDFIS TIKLESEAER AHHIQQIVVT LPRTIIIVMR YLFAFLNHLS QYSDENMMDP
     YNLAICFGPT LMPMPDGQDP VACQAHVNEV IKTIIIHTEV IFPSQRELDG PVYEKCMTGG
     EEYCDSPHSE PGTIDEADNG TEPHTSDEEV EQIEAIAKFD YVGRSPRELS FKKGASLLLY
     HRASEDWWEG RHNGVDGLIP HQYIVVQDLD DAFSDNLSQK ADSEASSGPL LEDKGSSKND
     VPSPCEQSPD YNFGGVMGRV RLRSDGAAIP RRRTDTQSPT RVADTPPRAA ACPSSPHKMS
     ISKGRMESPE KRRLGTFGSA GSINYPDRKT YPEGHPLRPV PGSTRHSSLG DHKSLETEAL
     AEDIEKTMNT ALHELRELER QNTVKQAPDV VLDTLEPMKN PVSSEPGSPL HTIMIRDPDA
     AMRRSSSSTS EMMTTFKPAL SARLAGAQLR PPPMRPVRPP PTQHRSSSSS SSGVGSPAVT
     PTEKMFPSNN TAAGSNVNIS SDGGDKSGTM
//