ID A0A3Q0SSY2_AMPCI Unreviewed; 1722 AA.
AC A0A3Q0SSY2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Myosin-11 {ECO:0000256|ARBA:ARBA00040393};
DE AltName: Full=Myosin heavy chain 11 {ECO:0000256|ARBA:ARBA00042406};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000023290.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000023290.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Muscle contraction. {ECO:0000256|ARBA:ARBA00037488}.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC {ECO:0000256|ARBA:ARBA00038612}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR STRING; 61819.ENSACIP00000023290; -.
DR Ensembl; ENSACIT00000023903.1; ENSACIP00000023290.1; ENSACIG00000018028.1.
DR GeneTree; ENSGT00940000155421; -.
DR OMA; NCACYLR; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.4820; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR PANTHER; PTHR45615:SF23; MYOSIN-11; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}.
FT DOMAIN 27..76
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 80..784
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 662..684
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1002..1032
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1116..1199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1556..1676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1560..1676
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 173..180
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1722 AA; 198353 MW; 2E447F212BB329C6 CRC64;
MADTDDNKYL FLENDFXNSG VAQADWAAKK MVWVPSEREG FEPASIKEEK GDQVLVELSN
GQKVTVNKDD IQKMNPPKFS KVEDMAALTF LNEASVLHNL RERYFSSLIY TYSGLFCVVV
NPYKMLPIYS EKIIEMYKGK KRHEVPPHIY SITDNAYRNM MQDREDQSIL CTGESGAGKT
ENTKKVIQYL AVVASSHKGK NPANPVSRNS FIGELEKQLL QANPILEAFG NAKTIKNDNS
SRFGKFIKLN FDVTGYLVGA NIDTYLLEKS RCIRQAHTER AFHIFYYMVA GAKDKVREEL
LLEDFSSYRF LIEGHVEIPG QEDDEMFDET LEAMEIMGFN EEERLGMLKV VSSVLQLGNI
KFEKERNNEQ ATMPDNTAAQ KVCHLQGINV TDFTRAILTP RIKVGREVVQ KAQTKQQADF
AIEALAKAMY ERLFRWILAR VNKTLDKSKR QSSSFLGILD IAGFEIFEDN SFEQLCINYT
NERLQQLFNH TMFILEQEEY KREGIEWNFI DFGLDLQPCI ELIERPNNPP GILALLDEEC
WFPKATDVSF VEKLLNTHTG HVKFSKPKQH KDKLMFSVLH YAGKVDYNAA NWLTKNMDPL
NDNVTALLNN SSSTFVQDLW KDVDRVVGLE TMTKMSESSV PSSTKSKKGM FRTVGQLYKE
SLGKLMTTLH NTQPNFVRCI IPNHEKRSGK MDSHLVLEQL RCNGVLEGIR ICRQGFPNRI
VFQEFRQRYE ILAANSIPKG FMDGKQACCL MVKHLDLDPN LYRIGQSKMF FRTGVLAQLE
EERDLKLTVV IIAFQAQARG FLGRKAFSKR QQQLSAMKVI QRNCACYLKL KNWQWWRLFT
KVKPLLQVTR QEEEMGQKEE ELKAAKEVAA KTEAELKDIT QKHSQLMEER AQLELKLQAE
TELCAEAEEM RVRLEAKKQE LEEVLHEMEA RLEEEEDRSN ALQQEKKEME QQLQLMEAHI
AKEEDAKQNL QLEKAAVEGK VKKLEEDILL MEDQNNKLQK ERKLLEERMA DMSSNLAEEE
EKSKNLTKLK AKHESMISEL EVRMKKEEKG RQDMEKAKRK VEAELAELQE QHADLQAQLA
ELQALTRTDD PFSQRGAAVK RIRELEALLS ELQEDLEAER AARGKAEAAR RDLGEELNAL
RTELEDSLDT TAAQQELRAK REQEVAMLKK AMEEEGRNHE AQIQELRQKH SQAVEELNEQ
LEQAKRVRAG LEKAKQALEK ESADLSSDLR SLASAKQDVE HKKKKVEGQL NELNSRFNES
ERQRNELSER VSKMTLELDS VTGLLNEAEG KNIKLSKDVS GLSSQLQDAQ ELLSEETRQK
LNLSGRLRQM EEDRNSLMEQ LEEETEAKRA VERQVSSLNM QLSDYKKKLD EMSGTVEMLE
EGKKRLQREL EAVNTEYEEK ASAYDKLEKS RSRMQQELED VLMDLDSQRQ LVSNLEKKQK
KFDQMLAEER SVSCKYAEER DRAEAEVREK ETKVLALTRA LEERHEALEE AEKMVKALRA
EMEDLISSKD DVGKNVHDLE KAKRGLEAIV EEMRTQMEEL EDELQVAEDA KLRLEVNSQA
LKAQHERELQ ARDELGEEKR KQLLKQVREL ESELEEERKQ RGQASAGKKK LEGELKDMED
QLEATSRGRD EALKQLRKIQ GQAKDLQREL EDSRAAQKEV LASARESERR SKAMEADIIH
LHEVLAAAER ARKQAETERD ELSEELASNS SGKWVSRVIN AF
//
