ID A0A3Q0ST21_AMPCI Unreviewed; 622 AA.
AC A0A3Q0ST21;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Dipeptidyl-peptidase 4 {ECO:0000313|Ensembl:ENSACIP00000025917.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000025917.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000025917.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC Cell projection, invadopodium membrane {ECO:0000256|ARBA:ARBA00004341};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004341}.
CC Cell projection, lamellipodium membrane
CC {ECO:0000256|ARBA:ARBA00004485}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004485}.
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DR AlphaFoldDB; A0A3Q0ST21; -.
DR Ensembl; ENSACIT00000026598.1; ENSACIP00000025917.1; ENSACIG00000019940.1.
DR GeneTree; ENSGT00940000163944; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0031258; C:lamellipodium membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF205; DIPEPTIDYL PEPTIDASE 4; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}.
FT DOMAIN 10..345
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 421..621
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
SQ SEQUENCE 622 AA; 70954 MW; FF114A2586EF2689 CRC64;
LEDVFNSSLK PKHSFTASYS LYDRESEKFI TPADIPDKVQ YFAWAPEGNK LAFVWNNNVY
IKTSPNSPPQ QVTSSGEENY LLNGIPDWVY EEEMFSSNQG LWWSPGGKYV AYAEFNETGV
HTIEYSWYGE NQYPSTVSIP YPKPGTPNPT VKLFVVDTDN TTKITEVVVP FNCSLFSHLS
EHYLATVTWV TDECLAVQWL KRVQNHLILQ LYNFTGSSWD PYEHLEVTSS GWIGRFSPPE
PVFAADKNSY YLLMSDIQQY KHIHHVGKAT AITSGRWEVI DILKVTADSV YFSSNEEGEC
LFHCFTFKSL LNKMNKTCYL RKNCQYNSAY FSHNAAYYRM ACSGQFYFLF DKQVLEDNEE
FASMISGIQM PTVREGAIKL GEYNLPYQMF LPPGFDESKK YPLLIDVYAG PCSQKVNSIY
RVSWSTYLAS SEKIIVASFD GRGSGYQGDK LMYEIYNSLG TKEVEDQITA AREFVKMGFI
DKNRVAIWGW SYGGYVTSMV LGSGSGVFKC GMAVAPVSKW HYYDSIYTER YMMEPSQNPE
GYDNTTVTAR AKNFHSVKYL LIHGTADDNV HFQQAAEISE ALVEAQVDFE AMWYTDKDHG
LSGAANKHVY THMTHFLLRC FA
//
