ID A0A3Q0STW8_AMPCI Unreviewed; 805 AA.
AC A0A3Q0STW8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0000313|Ensembl:ENSACIP00000028379.1};
GN Name=PTPRN2 {ECO:0000313|Ensembl:ENSACIP00000028379.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000028379.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000028379.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR AlphaFoldDB; A0A3Q0STW8; -.
DR STRING; 61819.ENSACIP00000028379; -.
DR Ensembl; ENSACIT00000029129.1; ENSACIP00000028379.1; ENSACIG00000021959.1.
DR GeneTree; ENSGT00940000154095; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 404..428
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 535..795
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 714..786
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 214..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..248
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..510
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 805 AA; 90204 MW; 2C5812B0A2A17DD6 CRC64;
MSNISQRKFH FKPENKNRNL QRSEIYTYDV SPSVVQHFRM LLEKLSNRGK HMHARTAFIS
AHVCLVKLGL FTNHAHMQII RNLDQRVKPV EVELSRNLQI YLQRLGLLPK TSASSLSASS
KVRIYSVCLF WVSVVRPVDD FVAHFNCGTN DVCFFAFDGY FTSICPPERF IKNVLKNVDR
QHVDVETLTP QDLDQLSSLI SEALQVVDQD QGLNRGLGQM RGPGPRDLEG ELSDGEEEGG
EEEEVSRDEL LENAPTLKPQ ESTPIALAVG LENVQSRTSE AGVAVQKKKK DATQSVEEVS
EVEGWIKEVA PPPASLVYDE PHKKTMHVPD LQLDVKASKK KGDDVFGYII TDTEVVGPAV
TFKVSPNAQN VSTADVANVA GRFSLESQIN QIPTKYSQTE STKFLILTIV SILCIVGVLL
ASTVVYCLRH RSHHKLKEKL TNLGTETSSD ATATYQELCR QRMAVKPPAE RPEPISSRIN
SVSSQFSDGG QAVSPSARSS ISSWSEEPAH SNMDISTGHM ILSYMEDHLK NKDRLEKEWE
ALCAYQAEPN ACTTGLKDGN SKKNRSTAVV AYDHSRITLK VENSQGNSDY INASPIMDHD
PRNPAYIATQ GPLPSTVADF WQMVWENGCV VIVMLTPLVE SGVKQCYHYW PDEGSNLYHI
YEVNLVSEHI WCDDFLVRSF YLKNMQTNET RTVTQFHFLT WLNQNVPETS RTLLDFRRKV
NKCYRGRSCP IIVHCSDGAG RTGTYILIDM VLNKMAKGAK EIDIAATLEH LRDQRPGMVQ
TKDQFEFALT AVAEEVNAIL KALPQ
//
