ID   A0A3Q0SUT3_AMPCI        Unreviewed;      1158 AA.
AC   A0A3Q0SUT3;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   SubName: Full=Transient receptor potential cation channel, subfamily M, member 5 {ECO:0000313|Ensembl:ENSACIP00000027281.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000027281.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000027281.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   STRING; 61819.ENSACIP00000027281; -.
DR   Ensembl; ENSACIT00000027998.1; ENSACIP00000027281.1; ENSACIG00000021027.1.
DR   GeneTree; ENSGT00940000160588; -.
DR   OMA; CYCTAVI; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR041491; TRPM_SLOG.
DR   PANTHER; PTHR13800:SF5; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY M MEMBER 5; 1.
DR   PANTHER; PTHR13800; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL, SUBFAMILY M, MEMBER 6; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF18139; LSDAT_euk; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023303};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00023303}.
FT   TRANSMEM        713..738
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        861..882
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        942..967
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          29..252
FT                   /note="TRPM SLOG"
FT                   /evidence="ECO:0000259|Pfam:PF18139"
FT   DOMAIN          729..979
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   REGION          1125..1158
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1126..1143
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1158 AA;  132094 MW;  81A84BFEFEFA2A41 CRC64;
     CVMNSAETLD KTGRVGDIDF LGPTKTRGKF VRVCSNTDPV LIYQMLTEEW GLSPPHLVVA
     LVGGDELAQM KPWLRDTLRK GLVKAAQSTG AWILTNGLRF GITKHLGQAV RDHSLASTSS
     KVRVVAIGIA PWNMIHNREA LITAKADEPA VYKPQDLPHG SVYSLDSHHS HFVLVEEDPN
     RPGATSEMRV KLLKHISLQR TGYGGAGSFE IPVLCLLVHG EPRILKRMYK GIGNSTPWLI
     LAGSGGVADI LVTLMNRGCW DTDSVHELLL DTFPNAHHST DISNWVKLVR ILEHEYLLTV
     HDPEQESSEL DTVILKALVK ACKSQSQEAQ DFLDELKLAV AWNRVDIAKS DIFNGDVEWK
     ACDLEEVMMD ALINDKPDFV RLFVDNGVNL GEFLTYGRLQ ELYWSVSEKS LFHNLLLKKY
     EEKQLLLGAA RTHGPPVHHP SEQGDRKPRF TLFEVAKVLK DFLHDSCKGF YQKTPTEKPA
     KGRLFHSQKN LAELEERCEH PWRDLFLWAV LQNRQQMANY FWAMGPEAVA AALAGCKILK
     EMARLESEAE SARSMKEAKY EQFALDVFGE CYSNSEDRAY ALLVRRTNCW SKSTVLNLAT
     EADAKSFFAH DGVQALLTKI WWGSMTTDTA ISKLVVSFFC PPLIWTNLIK FSDEELDXRN
     AGNQFVELDS LDTEKALLLS DDDDHLNSSP GGQTDQSCAS VWWRFLLRRW RRFWSAPVTV
     FLGNVIMYFA FLCLFTYVLL LDFRPPLPLG PGAPEIMLYF WVFTLVLEEL RQSFFTDEEI
     SILKKFKLYV EDNWNKCDMV AISLFVVGVS CRMVNDTYEA GRTVLAIDFM VFTLRLIHIF
     AIHKQLGPKI IIVERMMKDV FFFLFFLSVW LIAYGVATQA LLHPNDPRID WVFRRALYRP
     YLHIFGQIPL EEIDAARMPE MNCTNDSDEI IMGLRPPCPN VYANWLVILL LVIFLLVTNV
     LLLNLLIAMF SYTFQVVQGN TDIFWKFQRY NLIVEYHSRP ALAPPFIIIS HLSQLFLSLI
     KRPESKQEHL ERELPAELDQ RLITWETVQK ENYLAKLERQ HWESSEEKLK STSSKVQSLL
     KIVGGFKDQE KRLASMESQV RYCGEVLSWM AECFAQSTLK CGKEAPKVPS ESKISDRKKT
     KPGHPGYGAN KKFPYIDE
//