ID   A0A3Q0SV90_AMPCI        Unreviewed;       685 AA.
AC   A0A3Q0SV90;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   RecName: Full=Anoctamin {ECO:0000256|RuleBase:RU280814};
GN   Name=ANO1 {ECO:0000313|Ensembl:ENSACIP00000023950.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000023950.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000023950.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU280814}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU280814}.
CC   -!- SIMILARITY: Belongs to the anoctamin family.
CC       {ECO:0000256|ARBA:ARBA00009671, ECO:0000256|RuleBase:RU280814}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU280814}.
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DR   AlphaFoldDB; A0A3Q0SV90; -.
DR   Ensembl; ENSACIT00000024579.1; ENSACIP00000023950.1; ENSACIG00000018582.1.
DR   GeneTree; ENSGT00940000157182; -.
DR   OMA; QSEQGAF; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   InterPro; IPR032394; Anoct_dimer.
DR   InterPro; IPR007632; Anoctamin.
DR   InterPro; IPR049452; Anoctamin_TM.
DR   PANTHER; PTHR12308; ANOCTAMIN; 1.
DR   PANTHER; PTHR12308:SF13; ANOCTAMIN-1; 1.
DR   Pfam; PF16178; Anoct_dimer; 1.
DR   Pfam; PF04547; Anoctamin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280814};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU280814};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU280814}.
FT   TRANSMEM        58..82
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        135..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        216..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        258..282
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        302..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        427..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   TRANSMEM        484..507
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU280814"
FT   DOMAIN          2..44
FT                   /note="Anoctamin dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF16178"
FT   DOMAIN          47..621
FT                   /note="Anoctamin transmembrane"
FT                   /evidence="ECO:0000259|Pfam:PF04547"
SQ   SEQUENCE   685 AA;  79259 MW;  AE7EEFB17E2F860D CRC64;
     TGITSLLGSG VYTAAYPLHD VSSTLLLLYE EWANYSVFYK YQPIGLVRKY FGEKIGLYFA
     WLGLYTQMLI PASLVGVIVF LYGCATVDDN IPSMEICHPK NNITMCPLCD RVCSYWKLST
     ACGTARASHL FDNPATVFFS IFMALWAAMF MEHWKRRQMR LNYEWDLTGF EDEEDHPRAE
     YEFRVMQKSL RKGQKSQRKM EKLTFQDRLP AYMTNIVMLL LMIGVTFAIV FGVILYRIST
     KAALHMSSSL ITRNHVQLTV KTTAAIINLV VILILDEVYG AVARWLTVLE APKTDKSFEE
     RLIFKTFILK FVNAFTPIIY IAFFRGRLVG RPGSYLYVFD SYRMEECAHG GCLMELCIQL
     SITMLGKQLI QNNLFEIGIP KLKKLIRFIR SKRGGFQEEE RQKKLTRYET DHFLEPFGGL
     TPEYMEMIIQ FGFVTLFVAS FPLAPLFALL NNIIEIRLDA KKFVTELRRP VAARAKDIGI
     WYNILRGVAK VAVIINAFVI SFTSDFIPRM VYQYMYSTDG SMHGFVNHTL SYFNVSHFQE
     GKEPMDPSHL GYPVSICRYK DYREPPWSNT PYELSKEFWA VLAVRLAFVI VFQNVVMLMN
     DIIDWLIPDI PKDISLQIHK EKILLVELFM KEEQGKSYIL DTYLVPHKYP PHHNTTCPNC
     WQDTSTPSCC LHQILTLLFK CYSRN
//