ID   A0A3Q0SWJ6_AMPCI        Unreviewed;       759 AA.
AC   A0A3Q0SWJ6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Cullin 4A {ECO:0000313|Ensembl:ENSACIP00000029255.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029255.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000029255.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC       {ECO:0000256|ARBA:ARBA00004906}.
CC   -!- SIMILARITY: Belongs to the cullin family.
CC       {ECO:0000256|ARBA:ARBA00006019, ECO:0000256|PROSITE-ProRule:PRU00330,
CC       ECO:0000256|RuleBase:RU003829}.
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DR   AlphaFoldDB; A0A3Q0SWJ6; -.
DR   STRING; 61819.ENSACIP00000029255; -.
DR   Ensembl; ENSACIT00000030030.1; ENSACIP00000029255.1; ENSACIG00000022636.1.
DR   GeneTree; ENSGT00940000156905; -.
DR   OMA; NVVQSCF; -.
DR   UniPathway; UPA00143; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0031461; C:cullin-RING ubiquitin ligase complex; IEA:InterPro.
DR   GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:InterPro.
DR   GO; GO:0035118; P:embryonic pectoral fin morphogenesis; IEA:Ensembl.
DR   GO; GO:0007507; P:heart development; IEA:Ensembl.
DR   GO; GO:0071600; P:otic vesicle morphogenesis; IEA:Ensembl.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
DR   Gene3D; 1.20.1310.10; Cullin Repeats; 4.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR045093; Cullin.
DR   InterPro; IPR016157; Cullin_CS.
DR   InterPro; IPR016158; Cullin_homology.
DR   InterPro; IPR036317; Cullin_homology_sf.
DR   InterPro; IPR001373; Cullin_N.
DR   InterPro; IPR019559; Cullin_neddylation_domain.
DR   InterPro; IPR016159; Cullin_repeat-like_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11932; CULLIN; 1.
DR   PANTHER; PTHR11932:SF68; CULLIN-4A; 1.
DR   Pfam; PF00888; Cullin; 1.
DR   Pfam; PF10557; Cullin_Nedd8; 1.
DR   SMART; SM00182; CULLIN; 1.
DR   SMART; SM00884; Cullin_Nedd8; 1.
DR   SUPFAM; SSF75632; Cullin homology domain; 1.
DR   SUPFAM; SSF74788; Cullin repeat-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS01256; CULLIN_1; 1.
DR   PROSITE; PS50069; CULLIN_2; 1.
PE   3: Inferred from homology;
KW   Isopeptide bond {ECO:0000256|ARBA:ARBA00022499};
KW   Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   DOMAIN          417..632
FT                   /note="Cullin family profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50069"
SQ   SEQUENCE   759 AA;  88440 MW;  29E8002F80AE9CBC CRC64;
     MAEDTRQDKR ASFTAITEHS ANGMARTSAV ASGKTGTSKK LVIKNFKDRP KLAENYTEDT
     WLKLRDAVGA IQNSTSIKYN LEELYQAVEN LCSYKVSPTL YKQLRQVCED HVQAQIHQFR
     EYPFHSLDNL SFLKRMNRCW QDHCRQTIMI RSIFLFLDRT YVLQNSLLPS IWDTGLELFR
     THIVSDSAVQ KRTVEGILEQ IELERNGETV DRSLLRSLLG MLSDLQVYKD SFEERFLTET
     NRLYAAEGQR LMQERDVPEY LHHVARRLEE ENDRIVSYLD QSTQKPLISC VEKQLLGEHM
     TAILQKGLST LMDENRVTEL ALLYQLFSKV KGGLPTLLQF WRDYIKSFGG EIVCTPEKDK
     DMVQDLLDFK DKMDNVAQSC FARNESFINA MKEAFETFIN KRPNKPYKTV FVHLNKLRAG
     NKEATEEELE RILDKIMIIF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK
     HECGAAFTSK LEGMFKDMEL SKDIMIQFKQ YMQNQSEPSN IELTVNILTM GYWPSYTPME
     VHLPPEMVKL QEVFKLFYLG KHSGRKLQWQ PTLGHAVLKA EFKEGKKELQ VSLFQTLVLL
     MFNEGEEFSM EEIRAATGIE EGELRRTLQS LACGKARVLN KNPRGKDVED GDRFNFNNDF
     KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAV VRIMKMRKTL SHNLLVSELY
     NQLKFPVKPG DLKKRIESLI DRDYMERDKE TPNQYHYVA
//