ID   A0A3Q0SXE6_AMPCI        Unreviewed;       798 AA.
AC   A0A3Q0SXE6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029560.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000029560.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC       ECO:0000256|RuleBase:RU003722}.
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DR   AlphaFoldDB; A0A3Q0SXE6; -.
DR   Ensembl; ENSACIT00000030340.1; ENSACIP00000029560.1; ENSACIG00000022854.1.
DR   GeneTree; ENSGT00940000156807; -.
DR   OMA; INMFRTI; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR   GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR   Gene3D; 6.10.140.1330; -; 1.
DR   Gene3D; 6.10.250.2020; -; 1.
DR   InterPro; IPR006153; Cation/H_exchanger.
DR   InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR   InterPro; IPR004709; NaH_exchanger.
DR   InterPro; IPR032103; NHE_CaM-bd.
DR   NCBIfam; TIGR00840; b_cpa1; 1.
DR   PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR   PANTHER; PTHR10110:SF89; SODIUM_HYDROGEN EXCHANGER 2; 1.
DR   Pfam; PF00999; Na_H_Exchanger; 1.
DR   Pfam; PF16644; NEXCaM_BD; 1.
DR   PRINTS; PR01084; NAHEXCHNGR.
PE   3: Inferred from homology;
KW   Antiport {ECO:0000256|RuleBase:RU003722};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU003722};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|SAM:SignalP}; Sodium {ECO:0000256|ARBA:ARBA00023053};
KW   Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU003722};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           27..798
FT                   /note="Sodium/hydrogen exchanger"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018587830"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        95..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        124..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        159..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        225..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        309..333
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..371
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        383..406
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        421..439
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        448..472
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          74..472
FT                   /note="Cation/H+ exchanger"
FT                   /evidence="ECO:0000259|Pfam:PF00999"
FT   DOMAIN          567..668
FT                   /note="Sodium/hydrogen exchanger regulatory region"
FT                   /evidence="ECO:0000259|Pfam:PF16644"
FT   REGION          667..798
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        705..751
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   798 AA;  90284 MW;  9028DAF98F771419 CRC64;
     MDLIVIGRAG TLLFICTILN LLLCSGGEIH STTTAATIWP PVKPDRPQAY PEKEKSNLPL
     FTMNYSRIQI PFEIALWMLL ASFAKIGFNV YHKITIWVPE SCLLISIGLI VGGIMHAVKE
     EPPAVFTSSI FFLYMLPPIV LDSGYFMPTR PFFENIGTVL FFAVVGTLWN SIGIGIFLFA
     ICQIPAFGLQ DIDLPENLLF SAIISAVDPV AVLNVFEDVA VNEQLYIVVF GECLFSDAVT
     VVLYNMFSFV VELPVTEPVD VAFGVLRFFV VGLGGMGVGI LFGFVAAFNT RFTFKVREIE
     PLIILMYSYL AYLVAELFAI SSVMAIVTCA LTMKYYVEEN VSQHSCTTIR RVVKMLSSIS
     ETLLFFFLGV VTITTKHEWN WSYILFTLLF AFLWRSVGVL VLTQIINPFR TIPFNKKDQF
     GLAYGGLRGA ISFALAFTLP DNIGRRQLFI TATIAIILFT VFIQGISIRP LIEVINVRRT
     NRDTETINVE IHSRLMEHTV AGIEDLCGHW NHFYWKDKFM KFNNRILRKI LIRDSRAESS
     IVALYKKLEL QNAMEILDTV SGDIRFAPSI ISHHETKKRS TKPHKKLLAA DLKNMREILS
     KNMYKIRERT VAYRGKHALP NDSQTREILI RRHASIRRSL QSGSFQSMHL ITTLLFFSPP
     IPDDHETKSE FAYPSQRSRF GKPTHSTSRA MMPMHRLGTL KEVPSTDVLN EQSSSTGQRV
     FRTHSSYSDS RVPHSHHLNS SFDNSSADNL RNGHGEADAE QEARRQPSSP LPAWAAEPRD
     NTARNPLLRR PQWNPSKK
//