ID A0A3Q0SYE0_AMPCI Unreviewed; 600 AA.
AC A0A3Q0SYE0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000028802.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000028802.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; A0A3Q0SYE0; -.
DR STRING; 61819.ENSACIP00000028802; -.
DR Ensembl; ENSACIT00000029568.1; ENSACIP00000028802.1; ENSACIG00000022295.1.
DR GeneTree; ENSGT00940000153882; -.
DR OMA; WPSWGAV; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0021960; P:anterior commissure morphogenesis; IEA:Ensembl.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0071678; P:olfactory bulb axon guidance; IEA:Ensembl.
DR GO; GO:0030516; P:regulation of axon extension; IEA:Ensembl.
DR CDD; cd00055; EGF_Lam; 3.
DR CDD; cd03579; NTR_netrin-1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 2.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF435; LAMININ SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 46..283
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 284..339
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 403..452
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 471..600
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 286..303
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 305..314
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 403..415
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 405..422
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 424..433
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 436..450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 600 AA; 67608 MW; 664BB04EEFF558F4 CRC64;
MQRILEIWVT LVTVSALTKC VFGGYGFSMF AAQSSPPDPC YDENGNPRRC IPDFVNSAFG
KDVRVSSTCG TPAARYCVVT EKGEERTRDC HTCDAGDPKK SHPPAYLTDL NNPHNLTCWQ
SENYVQYPQN VTLTLSLGKK FEVTYVSLQF CSPRPESMAI YKSMDYGKSW VPFQFYSTQC
KKMYNRQNKA TITKQNEQEA ICTDSHTDMH PLTGGLIAFS TLDGRPSAHD FDNSPVLQDW
VTATDIKVIF SRLHTFGDEN EDDSELARDS YFYAVSDLQV GGRCKCNGHA SKCVKDREGN
LVCECKHNTA GPECDRCKPF HYDRPWQRAT AREANECVAC HCNLHARRCR FNMELYKLSG
RRSGGVCLNC RHNTAGRHCH YCKEGYYRDM TKSISHRRAC KACDCHPVGA AGKTCNQTTG
QCPCKDGVTG ITCNRCAKGY QQSRSPIAPC IKIPAASPTA TYSSYEEPTD CESHCKASKG
KMKITMKKYC KKDYAVQVHV LKGDKAGEWW KFTVNIISIY KQGEHRIRRG DQLLWVRAKD
VACKCPKIKP GRKYLLLGTD DDSPGQSGVV ADKGSLLIPW KDLWGRRLRK FQQRDKRGKC
//
