ID   A0A3Q0SYI0_AMPCI        Unreviewed;       857 AA.
AC   A0A3Q0SYI0;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Karyopherin (importin) beta 1 {ECO:0000313|Ensembl:ENSACIP00000029895.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029895.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000029895.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC       subfamily. {ECO:0000256|ARBA:ARBA00010907}.
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DR   AlphaFoldDB; A0A3Q0SYI0; -.
DR   STRING; 61819.ENSACIP00000029895; -.
DR   Ensembl; ENSACIT00000030678.1; ENSACIP00000029895.1; ENSACIG00000023130.1.
DR   GeneTree; ENSGT00550000074898; -.
DR   OMA; QQYQERW; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR   GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000225; Armadillo.
DR   InterPro; IPR021133; HEAT_type_2.
DR   InterPro; IPR001494; Importin-beta_N.
DR   InterPro; IPR040122; Importin_beta.
DR   PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR   PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR   Pfam; PF13513; HEAT_EZ; 1.
DR   Pfam; PF03810; IBN_N; 1.
DR   SMART; SM00185; ARM; 3.
DR   SMART; SM00913; IBN_N; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   PROSITE; PS50077; HEAT_REPEAT; 2.
DR   PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE   3: Inferred from homology;
FT   DOMAIN          1..81
FT                   /note="Importin N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50166"
FT   REPEAT          109..149
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT   REPEAT          389..426
FT                   /note="HEAT"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ   SEQUENCE   857 AA;  95201 MW;  EAABBD3AF35EAF47 CRC64;
     AQKFLEQAAI ENLPTFLVEL SKVLANPGNT QVARVAAGLQ VKNSLTSKDP DVKAQYQQRW
     LAIDANARRE IKNYVLQTLG TETYRPSSAS QCVAGIACAE IPVNQWPELI PQLVANVTDP
     SSTEHMKEST LEAIGYICQD IDPEQLQENA NQILTAIIQG MRKEEPSNNV KLAATNALLN
     SLEFTKANFD KDTERHFIMQ VVCEATQCPD TRVRVAALQN LVKIMSLYYQ YMETYMGPAL
     FAITIEAMKS DIDEVALQGI EFWSNVCDEE MDLAIEASEA SEQGRPPEHT SKFYAKGALQ
     YLVPILTQTL TKQDENDDDD DWNPCKAAGV CLMLLATCCE DDVVPHVLPF IKENIKHPDW
     RYRDASVMAF GSILEGPELN QLKPLVIQAM PTLIELMKDP SVVVRDTTAW TVGRICELLP
     EAAINEVYLA PLLQCLIEGL GAEPRVASNV CWAFSSLAEA AYEATDAAED QEEPSTYCLS
     SSFEIIVQKL LETTDRPDGH QNNLRSAAYE ALMEIVKNSA KDCYPAVQKT TLVIMERLQQ
     VLQMESHIQS TSDRIQFNDL QSLLCATLQN VLRKVQHQDA LQISDVVMAS LLRMFQSTAG
     SGGVQEDALM AVSTLVEVLG SDFQKYMDAF KPFLAIGLKN YAEYQVCLAA VGLVCDLCRA
     LMSNILPYCD EIMQLLLENL GNENVHRSVK PQILSAFGDI ALAIGGEFKK YLDIVLDTLQ
     QASQAQVDKT DYDMVDYLNE LREGCLEAYT GIIQGLKGDQ ENVHPDVMLV QPRVEFILSF
     IHHIAEDEDH SDGVVANAAG LIGDLCTAFG KDVMKLVEVR PLINDLLTEG RRSKTTKTKT
     LATWATKELR KLKSQAW
//