ID   A0A3Q0T0E5_AMPCI        Unreviewed;       797 AA.
AC   A0A3Q0T0E5;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 21.
DE   RecName: Full=SEFIR domain-containing protein {ECO:0000259|PROSITE:PS51534};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000027408.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000027408.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC       Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC       protein {ECO:0000256|ARBA:ARBA00004479}.
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DR   Ensembl; ENSACIT00000028129.1; ENSACIP00000027408.1; ENSACIG00000021210.1.
DR   GeneTree; ENSGT00940000159018; -.
DR   OMA; EPGRIHQ; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030368; F:interleukin-17 receptor activity; IEA:InterPro.
DR   Gene3D; 3.40.50.11530; -; 1.
DR   Gene3D; 2.60.40.2160; Interleukin-17 receptor A/B, fibronectin-III-like domain 1; 1.
DR   Gene3D; 2.60.40.2150; Interleukin-17 receptor A/B, fibronectin-III-like domain 2; 1.
DR   InterPro; IPR039465; IL-17_rcpt-like.
DR   InterPro; IPR032356; IL17R_fnIII_D1.
DR   InterPro; IPR038683; IL17RA/B_FnIII-like_1_sf.
DR   InterPro; IPR043046; IL17RA/B_FnIII-like_2_sf.
DR   InterPro; IPR013568; SEFIR_dom.
DR   PANTHER; PTHR15583; INTERLEUKIN-17 RECEPTOR; 1.
DR   PANTHER; PTHR15583:SF13; INTERLEUKIN-17 RECEPTOR A; 1.
DR   Pfam; PF16556; IL17R_fnIII_D1; 1.
DR   Pfam; PF08357; SEFIR; 1.
DR   PROSITE; PS51534; SEFIR; 1.
PE   4: Predicted;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..797
FT                   /note="SEFIR domain-containing protein"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5018782055"
FT   TRANSMEM        290..310
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          335..491
FT                   /note="SEFIR"
FT                   /evidence="ECO:0000259|PROSITE:PS51534"
FT   REGION          660..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          735..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   797 AA;  89653 MW;  BEBA01087D52D8B2 CRC64;
     VKMYRALLLL ICVPLSTTVW ILPGPLRCSR QVRKGFRESE GMCKDWLKVN DYTPSSPEDL
     KVSVEIRQDE AGRLQPVLDA RWKLKDDGSI RFLTATELHV LVTSTNQNLC VRYSFKNELK
     MRSPSGEQWS FSAGMLVLDP GQSYRVSVFN IPKPELNHSN YDISKNVKVD GDPQMQMTQF
     CIESGSLWQP NITLSQVPVV GGSSALAVSF STDRLCEEYM VIVRCPSVQH THRLKKANQT
     TLNVTFRRDE WPRSCCQFDA EVKLFKSVLQ SDVTTPLPLT AATDXPSYKF IALGVVVVIC
     VLMAVVMYAI CRKPGKTDAS AGPEGVPKPQ TVKQPPKVLV IYSQDHHLYR DIVLKLCAFL
     QTKCGTKVLV DLLDSTSVSM VGRLRWLEWQ RQQLKDPSDK ILVLCSRGVQ AKWKAMCGQG
     RVTLKEDLLS PTDDMLTPFL NLFLPEMHQA GMLGRYMVAY FDDISSEQDV PSVFDIAVKY
     SLMKHFEELY FRIVDIEKYQ PGQVNHFEGI GADEYFNCPS GSALRKAIET FQAYQXEHPD
     WFEKECVVSE EEVLNEANLH IEQFXIPPVL ECVPLIRDGL PVYVQDIEIN ENSTSIHILT
     PEQNPESQLS SVTELIPALN PKGRHQHSSG LEEVLTDHLC LHNPSAQSVY IAEPVLNKPP
     PPRQNWVSLE DEPLGQIPTE DDEDSLMPMS QPSAHLDQSC SALQNSLDLN SPEFSGTSIQ
     RQHFPCXEVD DSEPVLIEEG EDLEPKGPSS GSDQGYMSKI SSQPEFLFQE DSLVALARLQ
     EKLFQENLSC SEGNSVY
//