ID A0A3Q0T2J2_AMPCI Unreviewed; 1142 AA.
AC A0A3Q0T2J2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor), tandem duplicate 2 {ECO:0000313|Ensembl:ENSACIP00000026385.1};
GN Name=ITGA2 {ECO:0000313|Ensembl:ENSACIP00000026385.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000026385.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000026385.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR Ensembl; ENSACIT00000027078.1; ENSACIP00000026385.1; ENSACIG00000020338.1.
DR GeneTree; ENSGT00940000156303; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 2.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF23; INTEGRIN ALPHA-2; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 5.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 32..1142
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5018377911"
FT TRANSMEM 1094..1115
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1122..1139
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 36..94
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 176..362
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 424..476
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 477..540
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 541..599
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 603..663
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1142 AA; 124990 MW; 96BE80B3C14561AC CRC64;
CGVKLMSLTV EVVKQVLVLV LCSDSIWQAQ SFNLGTAGAK IFSGSATEEF GYTVQQVENH
QGKWLLVGAP WSGYSQNRKG NIYKCPIXGS QNSCDKLNLQ NSVSIPDVKN VNNNMSLGLT
LTRMTDEKGL MMCGPLWGQN CGTQNFYPGI CARLDPLFQP QPAISPAVQS CGGPMDIVIV
LDGSNSIFPW EPITDFLKKL LPTLDIGPQS TQVSVIQYAV YPKIEFTLNQ FETKDKMIVA
ASKITQMSGD MTNTFKAIEY ARLGFSESNG GRPGAAKVMV VVTDGESHDS SETKRVIASC
EKQGITRFGI AVLGYYTRNQ IDTKDLINEI KSIASSPTEK HFFNVSEEAV LSTIAGTLGD
RIFNIEGTGK GADNFKMEMS QVGFSTHYSS QQDVLMLGAV GAYAWSGTVV HQKGSKADIL
PFSAFEESLQ DRNHSSLLGY SVTTLRDGPT EYFVAGAPRS NHSGQVIVYT INAQKQSSII
DSQRGKQIGS YFGSVLCALD VDKDGTTDLL LVGAPMYMSE LKKEQGRVYL FSVTKGILNE
RGFLSGPPQT EDARFGMAIS AIPDLDLDGF SDVVVGAPLE DKGKGLIYIY NGQKKMLNTQ
FSQKILGSSL DPQLKYFGRS LDSYKDLNGD KLPDISVGAY GKVVQLWSRG VASVTVKASF
NPDKINVFNK PCSINGRKLS CFITNLCFTA AFRPTTPVGP IDITYTLTLD ADLLSSRVSS
RGMFTKNNER FLTEKAKVSS TDLCRDYQVY VQEAPDFVNS LSLKVEIGQE NVNANPVLDV
FSPNAQEFFI PFTKDCGSDE VCVSDLVLST LKKHKSSAPI LVSANNRELS FEVAVKNKKE
NAYNTQVVVT YSSNLYYSSV IPPVSNTRQK TYSSLNFEAK SDSEEETTTD NKVEISIPIR
YDTGIVLSRE ANIDFFVADA TTPVLTVKSF DDIGPEFSFT VKVSTSNFPV NLLSLTIALP
MTTKGGNPLL YVTRVETQAV ISCDYSNLVN PLKIGADIKK VSFSEESFRG MEKLDCKSAK
CEYIKCILKD MEIKSNYFVN VKTRIWNGTF ISVNIFSYRF YNSVETSNPD LLIIGNKQLS
VGLRVSKPGE KGDVPVGVIA GSVIAGLVLL ALAVVLLWKV RFFLFCFLSC GGTAVNYLYT
LG
//
