ID A0A3Q0T3M6_AMPCI Unreviewed; 1195 AA.
AC A0A3Q0T3M6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Ras protein specific guanine nucleotide releasing factor 1 {ECO:0000313|Ensembl:ENSACIP00000030718.1};
GN Name=RASGRF1 {ECO:0000313|Ensembl:ENSACIP00000030718.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000030718.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000030718.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A3Q0T3M6; -.
DR STRING; 61819.ENSACIP00000030718; -.
DR Ensembl; ENSACIT00000031521.1; ENSACIP00000030718.1; ENSACIG00000023747.1.
DR GeneTree; ENSGT00940000157599; -.
DR OMA; SCNTNGY; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd13261; PH_RasGRF1_2; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 2.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF193; RAS-SPECIFIC GUANINE NUCLEOTIDE-RELEASING FACTOR 1; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168}.
FT DOMAIN 22..129
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 240..426
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 467..583
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 630..745
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 960..1192
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 708..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 796..864
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 150..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 796..825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 831..860
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1195 AA; 136782 MW; 947FBCA759608C74 CRC64;
MQKGIRLNDG HVTYLGLLAK KDGTRRGCLS KKSSDNTKWH TKWFALLQNM LFYFENESSS
RPSGLYLLEG CICDRAPSPK PSLSAKECLE KQYYFTVSFN HENQKALELR TEDVKDCDEW
VAAISHASYR NLATEHEALM QKYLHLLQIV ETEKTVAKQL RQQIEDGEIE IERLKSEIAG
LLKDNEKIHA SPAAAPTDDD SEIKKIKKVQ SFLRGWICRR KWKTIIQDYI RSPHAESMRK
RNQVVFSMLD SEAEYVQQLH ILVNNFLRPL RMAASSKKPP ITHDDVSSIF LNSETIMFLH
QIFYQGLKAR IASWPTLVLA DLFDILLPML NIYQEFVRNH QYSLQILAHC KQNRDFDKLL
KQYEAKPDCE ERTLETFLTY PMFQIPRYIL TLHELLAHTP HEHVERNSLD YAKSKLEELS
RIMHDEVSET ENIRKNLAIE RMIVEGCEIL LDTSQTFVRQ GSLIQVPMSE KGKITRGRLG
SLSLKKEGER QCFLFSKHLI ICTRGSGGKL HLTKNGVVSL IDCTLVEDPE GTDEEYKSGQ
DMEHLDFKIV VEPKDSQSFT VILVASSRQE KSAWTSDISQ CIDNIRCNGL MMNAFEDNSK
VTVPQMIKSD SSLYCDDVDI RFSKMMNSCK VLQIRYASVE RLLERLTDLR FLSIDFLNTF
LHSYRVFTTA DVVLDKLITI YKKPISAIPA RSLELFFASS QNSKLLYGEP PSSPRASRKF
SSPPPLAIAK NSSPNRRRKL SLNIPIITGG KALDLAALSC SSNGYASMYS SMSPFSKTTL
DINKLYVSSP ITSKISDEGE DRKEKVDDTS SCKQDLSVRE ESDNDQNQSD EGDPEASPTK
SPTTPKNIKC KNSSGFPTDQ RNGDKEFVIR RAATNRVLNV LRHWVSKHSP DFDSNNELKT
KVIAFLEEVM HDPELLTQER KAAANIIRTI TQEDPGDNQI MIEDVTQLVR GKAETFENHS
ALEIAEQLTL LDHLVFKVIP YEEFFGQGWM KNDKNEKTPY IMRTTKHFND MSNLIATEIL
HCDDVVTRVA VIEKWVAVAD ICRCLHNYNA VLEITSSLNR SSVFRLKKTW LKVSKQTKAL
IDKLQKLVSS EGRFKNLREA LKNCDPPCVP YLGMYLTDLA FIEEGTPNYT EDNLVNFSKM
RMISHIIREI RQFQQTAYKI DLQPKVAQYL LDKSSVLDEE SMYEASLRIE PKVPN
//
