ID A0A3Q0T4Y5_AMPCI Unreviewed; 462 AA.
AC A0A3Q0T4Y5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=WD40 repeat-containing protein SMU1 {ECO:0000256|ARBA:ARBA00026184};
DE AltName: Full=Smu-1 suppressor of mec-8 and unc-52 protein homolog {ECO:0000256|ARBA:ARBA00031988};
GN Name=SMU1 {ECO:0000313|Ensembl:ENSACIP00000029873.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029873.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000029873.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC -!- SIMILARITY: Belongs to the WD repeat SMU1 family.
CC {ECO:0000256|ARBA:ARBA00025801}.
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DR AlphaFoldDB; A0A3Q0T4Y5; -.
DR STRING; 61819.ENSACIP00000029873; -.
DR Ensembl; ENSACIT00000030655.1; ENSACIP00000029873.1; ENSACIG00000023109.1.
DR GeneTree; ENSGT00940000155007; -.
DR OMA; MMKQQEP; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR006595; CTLH_C.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR045184; SMU1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22848; WD40 REPEAT PROTEIN; 1.
DR PANTHER; PTHR22848:SF0; WD40 REPEAT-CONTAINING PROTEIN SMU1; 1.
DR Pfam; PF17814; LisH_TPL; 1.
DR Pfam; PF00400; WD40; 5.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50897; CTLH; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 5.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 3: Inferred from homology;
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 40..79
FT /note="CTLH"
FT /evidence="ECO:0000259|PROSITE:PS50897"
FT REPEAT 159..200
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 209..250
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 252..293
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 294..335
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 429..462
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 462 AA; 51593 MW; 5FF0C5F94CE067C8 CRC64;
MSLEVESADV IRLIMQYLKE NNLHRTLATL QEETTVSLNT VDSIESFVAD INSGHWDTVL
QAIQSLKLPD KTLIDLYEQA YPDGSSKEKR RAAIAQALAG EVSVVPPSRL MALLGQALKW
QQHQGLLPPG MTIDLFRGKA AVKDVEEERF PTQLSRHIKF GQKSHVECSR FSPDGQYLVT
GSVDGFIEVW NFTTGKIRKD LKYQAQDNFM MMDDAVLCMC FSRDTEMLAT GAQDGKIKVW
KIQSGQCLRR FERGHSKGVT CLSFCKDSSQ LLSASFDQTI RIHGLKSGKT LKEFRGHSSF
VNEVTFTPDG HHIISASSDG TVKLWNMKTT ECSSTFKPLG TSAGTDITVN NVLLLPKNPE
HFVVCNRSNT VVIMNMQGQI VRSFSSGKRE GGDFVCCTLS PRGEWIYCVG EDFVLYCFST
VTGKLERTLT IHEKDVIGIA HHPHQNLIAT YSEDGLLKLW KP
//
