ID   A0A3Q0T5H2_AMPCI        Unreviewed;       771 AA.
AC   A0A3Q0T5H2;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   SubName: Full=Carnitine palmitoyltransferase 1Ab (liver) {ECO:0000313|Ensembl:ENSACIP00000031488.1};
GN   Name=CPT1A {ECO:0000313|Ensembl:ENSACIP00000031488.1};
OS   Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC   Cichlasomatinae; Heroini; Amphilophus.
OX   NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000031488.1, ECO:0000313|Proteomes:UP000261340};
RN   [1] {ECO:0000313|Ensembl:ENSACIP00000031488.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   AlphaFoldDB; A0A3Q0T5H2; -.
DR   STRING; 61819.ENSACIP00000031488; -.
DR   Ensembl; ENSACIT00000032315.1; ENSACIP00000031488.1; ENSACIG00000024332.1.
DR   GeneTree; ENSGT01060000248595; -.
DR   OMA; NTEHSWG; -.
DR   UniPathway; UPA00659; -.
DR   Proteomes; UP000261340; Unplaced.
DR   GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR   GO; GO:0001945; P:lymph vessel development; IEA:Ensembl.
DR   GO; GO:0031998; P:regulation of fatty acid beta-oxidation; IEA:Ensembl.
DR   Gene3D; 6.10.250.1760; -; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   InterPro; IPR032476; CPT_N.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF55; CARNITINE O-PALMITOYLTRANSFERASE 1, BRAIN ISOFORM; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   Pfam; PF16484; CPT_N; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        105..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..47
FT                   /note="Carnitine O-palmitoyltransferase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16484"
FT   DOMAIN          175..754
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        473
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   771 AA;  88611 MW;  AF73E5582CA3E95D CRC64;
     MAEAHQAVAF QFTVTPEGID LQLSHEALRQ VYLSGLHSWK KRFIRFKNGV MTGVYPGSPA
     GFSIVVGSYM TYNKFKQLDP SLGLFTKLGQ HIPISRYMST DTQRIVGGVL VGTGLWVTII
     MIMRNVLKSL LSWHGWMQER HGSLSWSTRV WMILVKVFSG RKPMLYSFQN SLPRLPLPSI
     KDTCQRYLES VRPLMDDKKY ERMEGLTQDF EKNLGPRLQW YLKLKSWWAS NYVSDWWEEY
     IYLRGRGPIM VNSNYYAMDF LYVFPTSIQA ARAGNSIHAI MLYRRKLDRA QIKPLMLLHT
     IPMCSAQYER MFNTTRVPGV ETDTLQHVNE SKHIVVYHKG RFFKVWIFYD GRLLLPREIE
     QQMERILADK SEPLPGEEKL AALTAGDRTP WAKARETYFS RGKNKQSLDA IEKAAFFVTL
     DDTEQRYDAD NPVTSLDSYA KSLLHGKCYD RWFDKSFNLI VFKNGTMGLN AEHSWADAPI
     IGHLWEHVLY MDPRLGYTED GHCVGQPHPN LPGPQRLQWD IPAECQEAIE GSFTVARTLA
     DDVDCDIIPF TDFGKGLIKK CRTSPDAFIQ ISLQLAHYRD KAKFCLTYEA SMTRMFREGR
     TETVRSCTTE TCAFVLSMIR DETREERLRL LKLAAEKHQS LYRLAMTGQG IDRHLFCLYV
     VSKYLGEDSP FLKEVLSEPW RLSTSQTPMQ QVELFDLVRH PEYVSSGGGF GPVADDGYGV
     SYIILGESLI NFHISSKRSS PETDSHRFGT NIRQAMLDIL GLFELNNKAA K
//