ID A0A3Q0T6W0_AMPCI Unreviewed; 1770 AA.
AC A0A3Q0T6W0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Voltage-dependent L-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029809.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000029809.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry
CC of calcium ions into excitable cells and are also involved in a variety
CC of calcium-dependent processes, including muscle contraction, hormone
CC or neurotransmitter release, gene expression, cell motility, cell
CC division and cell death. {ECO:0000256|RuleBase:RU003808}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
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DR STRING; 61819.ENSACIP00000029809; -.
DR Ensembl; ENSACIT00000030590.1; ENSACIP00000029809.1; ENSACIG00000022926.1.
DR GeneTree; ENSGT00940000158289; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 4.
DR InterPro; IPR031688; CAC1F_C.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR005450; VDCC_L_a1ssu.
DR InterPro; IPR005446; VDCC_L_a1su.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF9; VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1S; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16885; CAC1F_C; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR PRINTS; PR01630; LVDCCALPHA1.
DR PRINTS; PR01634; LVDCCALPHA1S.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180, ECO:0000256|PIRSR:PIRSR602077-
KW 3}; Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 102..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..153
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..340
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 440..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 473..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 566..589
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 610..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..668
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 778..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 818..836
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 857..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 903..932
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1028..1055
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1098..1120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1140..1159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1257..1280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1349..1372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1388..1423
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 720..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1608..1679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1730..1770
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 299
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 621
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1001
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 1770 AA; 200839 MW; 3908E48606EFB047 CRC64;
MASNTEAAKP IIMNEEELKR KQREKLKKLQ ATGGNPRPAR SLFLFNLKNP FRKACINIVE
WKTFEVIILL TIFANCIALA VFLPMPEEDT NNTNLNLESL EYIFLIIFTL ECFLKIIAYG
FVFHEGAYLR NCWNILDFVI VFMGLFTLFM DTVNMVSGVP KEKGGGFDMK ALRAFRVLRP
LRLVSGVPSL QVVMNSILKA MLPLLHIALL VFLLVTIYAI MGLELFKCKM HKTCYYTDTN
IYAMAEGELP APCAQAGNGR RCNNGSECRP GWEGPNNGIT HFDNIGFAML TVYQCITMEG
WTKVLYWVND AIGNEWPWLY FVTLILLGSF FVLNLVLGVL SGEFTKEREK ARSRGEFQKL
RERQQLDEDL HGYMEWITHA EVLDADREGK GLLPLTSGDS DTDSLYDLEG KSQIIYYYRL
ARRWNRFLRM KCLVYVKTKA FYWVVMFLVF LNTLTIATEY HHQPDSLTSF QDVASRVLLV
LFVIEMFVKM YALGPRAYFM SLFNRFDFFV VLCGILEMIM LSAGAVAPLG FSVLRCIRLL
RILKVTKYWK SLSNLVASLL NSVRSIASLL LLLFLFIVIF SLLGMQVFGG KFNFSDHRPR
RSNFDNFPQA LISVFQILTG EDWTSIMYNG IMAYGGPVIP GILVSIYFII LFVCGNYILL
NVFLAIAVDN LAEAESLTSA QKEKAEEKLR KKLLRAKMEG MPTTAKLKID EFESNVNEVK
DPFPPADFPG DDEEEEPEIP ISPRPRPMAD LQLKEEAVPL PEASSFFIFG PQNKFRKLCY
KIINASSFTN LILLFILLSS ISLAAEDPID PKSYRNQILA YADIVFTSVF TIEIVLKMTV
YGAFMHKGSF CRNSFNILDL IVVGVSLLSM GMESSAISVV KILRVLRVLR PLRAINRAKG
LKHVVQCVFV AIKTIGNIVL VTLLLNFMFA CIGVQLFKGK FYSCTDVSKM TKEECQGFFL
KHMENSLQDT VVAKREWLNS DFNFDNVLNG ILALFTVSTF EGWPKLLYRA IDSAQEDMGP
VFNNRVDVSI FFIIYIILIA FFMMNIFVGF VIVTFQEQGE QEYKNCELDK NQRQCVQYAL
KARPLRCYIP KNPNQYRVWY IVTSCYFEYL MFFLIMLNTL CLGMQHCNQS DHVTKLSDTL
NLIFTVLFTV EMILKLMAFK ARGYFGDPWN VFDFIIVVGS VVDVILSEVD SALTESGGLY
CLHGCETNPM QVIADSENAS VSITFFRLFR VMRLVKLLNR SEGIRNLLWT FIKSFQALPH
VALLIVMLFF IYAVIGMQIF GKIALMDGTQ INRNNNFQTF PQAVLMLFRC ATGEAWQEVM
MASMYGKKCD PMSDILPGEE YTCGSNFAVF YFLSFYCLCA FLILNLFVAV IMDNFDYLTR
DWSLLGPHHL DEFKKIWAEY DPEATGRIKH LDVVTLLRSI QPPLGFGKFC PHRAACKRLV
GMNMPLNSDG TVTFNATLFA LVRTALKIKT EGNFEQANEE LRAIIKQIWK RTSMKLLDQV
IPPIGDDEVT VGKFYATFLL QDHLRKFIKH QEEYYGYRPT KKSASGPEIQ AGLRSIEEEA
APEMHRAISG DLQNEEEMER AMEEAGEEAI YQRSHHLFGN RVESFSAEPA NTQSQQMTNQ
RPLSFTESQP ESPPSSASAL VPGTEFFPTT PPKSNTNNNA FFPYDPNYGD SQSQSSHTAA
DQLVQEALEN GGLVSLARDP SFVSLTKKEM AEAMHIPIAE MEGVAQGILN EPPAVPKVEK
GQPDPAVRRK RRPIPTVPST KGPSEADSGV
//
