ID A0A3Q0T7C6_AMPCI Unreviewed; 1241 AA.
AC A0A3Q0T7C6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=L1 cell adhesion molecule, paralog a {ECO:0000313|Ensembl:ENSACIP00000029954.1};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029954.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000029954.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; A0A3Q0T7C6; -.
DR Ensembl; ENSACIT00000030739.1; ENSACIP00000029954.1; ENSACIG00000023139.1.
DR GeneTree; ENSGT00940000157506; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 11.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF44; L1 CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..1241
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018612012"
FT TRANSMEM 1100..1121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 49..144
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 226..314
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 319..407
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 413..482
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 483..589
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 596..691
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 696..790
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 795..900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 904..998
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1000..1094
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 677..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1129..1149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1197..1241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1218..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1241 AA; 138117 MW; FDC4EDC3FB2EC8E5 CRC64;
AMPHMQRQQV VSRGQCSSCL LPLVLVLLSL ATQPSQAAIQ IPPNFRRPPV ITTQPESVTV
FSVEDLVMSC EASGNPPPIF RWTKDGEDFD PGSDPELKVS ERSGSFAFYT LSNTMDTLTK
YQGKYVCYAS NELGTAVSNE AILNTDGKNA VTTYKPLTTF CNHLSLRERV MLGKDGNLYF
ASLDISDSRD DYTCNVQYLA TRTILAKEPI TLKVVPSNSI LRNRRPQMMR PAGKHSTYHA
LRGQTLELEC IVQGLPTPEV SWLRKDGEFS ESRTSKDMFD RRLRFTNISE SDGGEYQCIA
ENSQGKATHT YMLTVEAAPY WVKEPVSQLY APGETVKLDC QADGIPFPTI SWTINGVPIS
EVDKDSSRTL TASGSLILED VNFRDTAIYQ CWASNKHGTI LTNTNVYVIE LPPQLLTEDG
NTYAYTEGQK ALLECETFGR IAYSCAYCSS LLADPRVNPL ANGWLEISNV TQSDDGIYTC
TVPNTNLSIS AELEIFNRTV ILSPPQALKV QPGHTAIFTC LALVDPRLDF PFIQWRKNNQ
KLADSNSDEK YTMEGSDLII ANVQLEDEGV YTCEIISKLD VAEARGTLTL CDRPDPPILL
QISDPKHREV TLSWTPGDDH NSPVTEYVVE FEEQGSKERG WEELKRVSGN KERADLTLWP
YMSYRFRVIA INDVGKSNPS KPSEIHSTPA EAPDTNPEDV RSDSINPNTL VITWEKMDKR
NFHGPDFKYC VQWRRAVGGG PDWHEKNVTD PPFHVDNVGN FSAFEIKVQA FNEIGRGPEP
DPVIGYSGED VPLEAPMDVG VVLLNSTTIK VTWAPIDKET VRGHLLGYKI HYTRTGSKGH
HRGRRARELE SMVVDTEPNE QKKVISDLRP FSHYSLEVAV YNKKGEGPRS EALTFETPEG
VPGPPLTLTL DSPSETEMTL CWTPPGQPNG VLVGYLLQYQ EKTDDSPMQV EEIDGAAVTH
FTLKNLDRDS HYRFYVRGRT ATRHGVPIMM KGATTLDGVA PTNISLSVGE NSVNFSWVVK
KRHRNVGFQI HYLNKNDGSK WKKTEKVNSS QSFYQLQGLT PGSHYLLRFI YNNETFYKTD
IETEGTGVTE MQPSFATQGW FIGVVSAIGL LLLILLILCF IKRSKGGKYS VKDKEEGPMD
SEARPMKDET FGEYSDLEEK RTASQPSLCE GSKLCSEDNL DYNGSSAMTT ELNMDESLAS
QISRPSGGPE GFHGLPDNSP LNPTSFSPAT NGVPNSVTIL D
//
