ID A0A3Q0TC00_AMPCI Unreviewed; 83 AA.
AC A0A3Q0TC00;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Anaphase-promoting complex subunit 16 {ECO:0000256|ARBA:ARBA00013930};
DE AltName: Full=Cyclosome subunit 16 {ECO:0000256|ARBA:ARBA00031333};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000031735.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000031735.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Component of the anaphase promoting complex/cyclosome
CC (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls
CC progression through mitosis and the G1 phase of the cell cycle. The
CC APC/C complex acts by mediating ubiquitination and subsequent
CC degradation of target proteins: it mainly mediates the formation of
CC 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the
CC formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
CC {ECO:0000256|ARBA:ARBA00025025}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the APC16 family.
CC {ECO:0000256|ARBA:ARBA00007252}.
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DR AlphaFoldDB; A0A3Q0TC00; -.
DR STRING; 61819.ENSACIP00000031735; -.
DR Ensembl; ENSACIT00000032567.1; ENSACIP00000031735.1; ENSACIG00000024516.1.
DR GeneTree; ENSGT00390000018109; -.
DR OMA; LEADEWW; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR InterPro; IPR029641; APC16.
DR PANTHER; PTHR31564; ANAPHASE-PROMOTING COMPLEX SUBUNIT 16; 1.
DR PANTHER; PTHR31564:SF0; ANAPHASE-PROMOTING COMPLEX SUBUNIT 16; 1.
DR Pfam; PF17256; ANAPC16; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 83 AA; 8834 MW; 40EFB84464DE5978 CRC64;
MAASSSSSSA GGVSGSSVTG SGFSASELIP PRKVLYTYPK GAGEMMEDQQ VSRMEKLASL
VEELEADEWR YKPIEQLLGF TPS
//
