ID A0A3Q0TC63_AMPCI Unreviewed; 354 AA.
AC A0A3Q0TC63;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Synaptotagmin {ECO:0000256|RuleBase:RU367154};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000029686.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000029686.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: May have a regulatory role in the membrane interactions
CC during trafficking of synaptic vesicles at the active zone of the
CC synapse. It binds acidic phospholipids with a specificity that requires
CC the presence of both an acidic head group and a diacyl backbone.
CC {ECO:0000256|RuleBase:RU367154}.
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|RuleBase:RU367154};
CC Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2
CC domains. {ECO:0000256|RuleBase:RU367154};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004160}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004160}. Cytoplasmic vesicle, secretory
CC vesicle, chromaffin granule membrane {ECO:0000256|ARBA:ARBA00004349};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004349}.
CC Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004254, ECO:0000256|RuleBase:RU367154}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004254,
CC ECO:0000256|RuleBase:RU367154}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the synaptotagmin family.
CC {ECO:0000256|ARBA:ARBA00006996, ECO:0000256|RuleBase:RU367154}.
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DR AlphaFoldDB; A0A3Q0TC63; -.
DR STRING; 61819.ENSACIP00000029686; -.
DR Ensembl; ENSACIT00000030466.1; ENSACIP00000029686.1; ENSACIG00000022976.1.
DR GeneTree; ENSGT00940000155394; -.
DR OMA; FVPTAGK; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0042584; C:chromaffin granule membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR CDD; cd08402; C2B_Synaptotagmin-1; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001565; Synaptotagmin.
DR PANTHER; PTHR10024; SYNAPTOTAGMIN; 1.
DR PANTHER; PTHR10024:SF239; SYNAPTOTAGMIN-1; 1.
DR Pfam; PF00168; C2; 2.
DR PRINTS; PR00360; C2DOMAIN.
DR PRINTS; PR00399; SYNAPTOTAGMN.
DR SMART; SM00239; C2; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR PROSITE; PS50004; C2; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU367154};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|RuleBase:RU367154};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Metal-binding {ECO:0000256|RuleBase:RU367154};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Synapse {ECO:0000256|RuleBase:RU367154}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..354
FT /note="Synaptotagmin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018685405"
FT DOMAIN 65..193
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 205..338
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 29..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 354 AA; 39919 MW; 550418960FE9FC3F CRC64;
AALCIVSLCM VLSCAVCVWK KFLKKKDKGK EKEKDKKKGK EKSKGDFDTE MDGGYNEVSC
NTATPPPHPP QTHWPYSLFS PLHSPVIMFQ LVVGILQAAE LPAMDVGGSS DPYVKLYLLP
DKKKKFETKV HRKTLEPNFN ETFTFKVPYT ELGGKTLVMT VYDFDRFSKH DAIGAVKIPM
SGVDFSQSLQ EWRDLQKAEK EESERLGDIC LSLRYVPTAG KLTVVILEAK NLKKMDVGGL
SDPYVKIHLM QNGKRLKKKK TTIKKNTLNP YYNESFSFEV PCEQIEKVQV AVTVLDYDKI
GKNDAIGKML LGGNSTGTEQ RHWSDMLANP RRPIAQWHSL QPEDEVNALI SSKK
//
