ID A0A3Q0THZ5_AMPCI Unreviewed; 706 AA.
AC A0A3Q0THZ5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Prestin {ECO:0000256|ARBA:ARBA00040148};
DE AltName: Full=Solute carrier family 26 member 5 {ECO:0000256|ARBA:ARBA00042390};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000031662.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000031662.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR AlphaFoldDB; A0A3Q0THZ5; -.
DR STRING; 61819.ENSACIP00000031662; -.
DR Ensembl; ENSACIT00000032492.1; ENSACIP00000031662.1; ENSACIG00000024458.1.
DR GeneTree; ENSGT01070000253775; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0015499; F:formate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0160046; F:oxalate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0160044; F:sulfate:chloride antiporter activity; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF32; PRESTIN; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 107..134
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 140..157
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 189..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 302..319
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 325..348
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 387..403
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 424..446
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 466..498
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 522..690
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 706 AA; 77288 MW; 6C3E4A2367A670E4 CRC64;
MEQEETAVVI AAAAREGEDS QLIYRIQRPV YNETVIRTQL LNRKENTTTV CQKLAQKFQC
SSKKAKAVAL SFLPILTWLP SYPVKKYLFA DVVSGLSTGV VQLPQGLAYA LLAAVPPVYG
LYSSFYPVLL YTFFGTSRHV SIGTFAVISL MIGGVAVREA PDNDFLSANA SNMSEAIDVR
GRDAKRIEVA VMVTTLVGII QIVLGLLRFG FVAIYLTEPL VRGFTTAASM HVVISQLKYL
LGVETQRFSG PLSAIYVSLN NVRNKIPSTN VPTLLLGLAC LVFLYVIKVL NERFKKKLPI
PIPGEIIIVI VSTGVSYGLS LSKDYNVHIV GTIPTGLLLP TAPNFFLLPK LLTDSFAIAI
VGFSMDISLA KIFALKYGYS VDGNQELIAL GLCNFIGSFF QTFSVTSSMS RSLVQESTGG
KTQFFALMLG SVFQTALAAI IMVNLIGMFK QFRDIPALWR TSKIELAIWL AAFVASVLLG
LDYGLLVSIA FAILTVIYRT QSPKSSIMGH VPDTGLYCDV DEYEEAAEIE GIKIFHSNSS
IYFANSDLYV NTLKEKTGIN PEDLQTARKY KDEAVTHEVL PQDYVVVEDQ KNGQLGNRQG
DSNSEEAVFL EPLSTVHSII LDWTAATFID SVGAKAIKQA IKDYATVDVR VVIACCNRNL
LVELDDLQFF TKDMTTDIVF PTVHDAVLHC LYSNSHASAA PTSSTT
//