ID A0A3Q0TI84_AMPCI Unreviewed; 191 AA.
AC A0A3Q0TI84;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial {ECO:0000256|ARBA:ARBA00020530, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=Complex I-ASHI {ECO:0000256|ARBA:ARBA00032752, ECO:0000256|PIRNR:PIRNR009288};
DE AltName: Full=NADH-ubiquinone oxidoreductase ASHI subunit {ECO:0000256|ARBA:ARBA00032699, ECO:0000256|PIRNR:PIRNR009288};
OS Amphilophus citrinellus (Midas cichlid) (Cichlasoma citrinellum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; New World cichlids;
OC Cichlasomatinae; Heroini; Amphilophus.
OX NCBI_TaxID=61819 {ECO:0000313|Ensembl:ENSACIP00000031752.1, ECO:0000313|Proteomes:UP000261340};
RN [1] {ECO:0000313|Ensembl:ENSACIP00000031752.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Accessory subunit of the mitochondrial membrane respiratory
CC chain NADH dehydrogenase (Complex I), that is believed not to be
CC involved in catalysis. Complex I functions in the transfer of electrons
CC from NADH to the respiratory chain. The immediate electron acceptor for
CC the enzyme is believed to be ubiquinone.
CC {ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBUNIT: Complex I is composed of 45 different subunits.
CC {ECO:0000256|ARBA:ARBA00011533, ECO:0000256|PIRNR:PIRNR009288}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000256|ARBA:ARBA00004298}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004298}; Matrix side
CC {ECO:0000256|ARBA:ARBA00004298}.
CC -!- SIMILARITY: Belongs to the complex I NDUFB8 subunit family.
CC {ECO:0000256|ARBA:ARBA00008039, ECO:0000256|PIRNR:PIRNR009288}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q0TI84; -.
DR STRING; 61819.ENSACIP00000031752; -.
DR Ensembl; ENSACIT00000032584.1; ENSACIP00000031752.1; ENSACIG00000024521.1.
DR GeneTree; ENSGT00390000000628; -.
DR OMA; PRYKNSY; -.
DR Proteomes; UP000261340; Unplaced.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:UniProtKB-UniRule.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:UniProtKB-UniRule.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:UniProtKB-UniRule.
DR InterPro; IPR008699; NDUFB8.
DR InterPro; IPR016551; Ndufb8_metazoa.
DR PANTHER; PTHR12840:SF1; NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL; 1.
DR PANTHER; PTHR12840; NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT; 1.
DR Pfam; PF05821; NDUF_B8; 1.
DR PIRSF; PIRSF009288; NDUB8; 1.
PE 3: Inferred from homology;
KW Electron transport {ECO:0000256|PIRNR:PIRNR009288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion {ECO:0000256|PIRNR:PIRNR009288};
KW Mitochondrion inner membrane {ECO:0000256|PIRNR:PIRNR009288};
KW Respiratory chain {ECO:0000256|PIRNR:PIRNR009288};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR009288}.
FT TRANSMEM 129..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 29..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 71..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 191 AA; 22258 MW; 5FF53D6EA43AB350 CRC64;
MRTSESVEQQ QPVNMAGVGF RRWAQALSKG KGSASGLSKD SLPGPYPKTP EERAAAAKKY
NMRVEDYEPY PDNGEGFGDY PKLPERSQQE RDPWYQWDHP DLRRNWGEPM HWDFDMYIRN
RVDTSPSPVS WSTMCKQLFG FIGFMLFMFY VGEKFPSYQP VAPKQYPYSD LYLEKGGDSE
KQPEEVKHYE I
//