ID A0A3Q1AKR7_AMPOC Unreviewed; 336 AA.
AC A0A3Q1AKR7;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Tumor suppressor candidate 3 {ECO:0000313|Ensembl:ENSAOCP00000001329.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000001329.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000001329.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OST3/OST6 family.
CC {ECO:0000256|ARBA:ARBA00009561}.
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DR AlphaFoldDB; A0A3Q1AKR7; -.
DR STRING; 80972.ENSAOCP00000001329; -.
DR Ensembl; ENSAOCT00000013412.1; ENSAOCP00000001329.1; ENSAOCG00000000153.1.
DR GeneTree; ENSGT00390000012030; -.
DR OMA; VLFGMYS; -.
DR OrthoDB; 4604288at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015693; P:magnesium ion transport; IEA:Ensembl.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02947; TRX_family; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 1.
DR InterPro; IPR021149; OligosaccharylTrfase_OST3/OST6.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR PANTHER; PTHR12692; DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR12692:SF1; TUMOR SUPPRESSOR CANDIDATE 3; 1.
DR Pfam; PF04756; OST3_OST6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..336
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018618686"
FT TRANSMEM 187..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 272..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 336 AA; 37999 MW; 197D2428AC54DCB3 CRC64;
MASVWAKSAV NLHILAVFFF LLICLPSGGG QKKKENLLSE KVDQMMEWSS RRSVVRMNGD
KFRRFVKAPP RNYSVIVMFT ALQPQRQCSV CRQANEEYQV LANSWRYSSA FSNKLFFTVV
DYDEGADVFQ QLNMNSAPTF MHFPAKGKPK RADTFDLQRI GFASEQLAKW IADRTDVQIR
VFRPPNYSGT IALALLVSLV GGLLYLRRNN LEFIYNKTGW AMAALCVVFA MTSGQMWNHI
RGPPYAHKNP QNGQVSYIHG SSQAQFVAES HIILLLNAAI TMGMVLLNEA ATSKGDVGKR
RIICLVGLGL VVFFFSFLLS IFRSKYHGYP YSFLIK
//
