ID A0A3Q1AKY0_AMPOC Unreviewed; 807 AA.
AC A0A3Q1AKY0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Bromodomain-containing protein 2 {ECO:0000256|ARBA:ARBA00040998};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000001763.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000001763.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Homodimer. Interacts with E2F1 and with histone H4 acetylated
CC at 'Lys-13'. {ECO:0000256|ARBA:ARBA00038820}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A3Q1AKY0; -.
DR Ensembl; ENSAOCT00000012653.1; ENSAOCP00000001763.1; ENSAOCG00000004842.1.
DR GeneTree; ENSGT00940000153385; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR CDD; cd05497; Bromo_Brdt_I_like; 1.
DR CDD; cd05498; Bromo_Brdt_II_like; 1.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; Bromodomain-like; 2.
DR InterPro; IPR043508; Bromo_Brdt_I.
DR InterPro; IPR043509; Bromo_Brdt_II.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR PANTHER; PTHR22880:SF240; BROMODOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR22880; FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS; 1.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 2.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00297; BROMO; 2.
DR SUPFAM; SSF47370; Bromodomain; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 2.
DR PROSITE; PS50014; BROMODOMAIN_2; 2.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 92..164
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 416..488
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 670..752
FT /note="NET"
FT /evidence="ECO:0000259|PROSITE:PS51525"
FT REGION 52..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..286
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..552
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 567..663
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..69
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..595
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 807 AA; 89376 MW; 11F3A0D717F3CE7C CRC64;
MDMAVNPPFD SSHVGVEIGM LGVTMDHGSG AAGKRIRKPS LLYEGFESPG LPPLTQMVPS
GPPQPPVKDP SRQGRMTNQL QFLQKVLLKS LWRHHFAWPF HEPVDAAKLS LPDYHKIIKN
PMDMGTIKKR LENNYYRSAS ECMQDFNTMF TNCYIYNKPT DDIVLMAQSL EKAFLQKVAQ
MPQDELELPP PTPRSKTVKP GRKGRSNTVS GGITTAHQVP AVSQSVYSPP TPETPDSILS
TPPQTLLSKS LPLTLPPEQS IPTITGLPPT QPTAKKKGVK RKADTTTPTT VAMPIMSTMG
VSGISLGMGG GHDSPLTLTS LGVDHSSSMG MNPGLTLGQG MGMGMGMGMS MGMGRGAMIV
GTKATAASRR GVSGRPIKPP KKDLPDSILP PPVRRSKLSP QLRYCNGVLK ELLSKKHAAY
AWPFYKPVDA TTLGLHDYHD IIKQPMDLST IKRKMDSREY RDSQQFSADV RLMFSNCYKY
NPPDHDVVAM ARKLQDVFEF CFAKMPDEPP APPSSSSSSS SSSSSSESEL SSESEESESS
PSSDSEEERA NRLAELQEQL KAVHEQLTAL SQGPIVKPKK KKEKKDKKKK KKVEKEKHRK
VEEEPPPIKP PKTPKITKTP KPKSNRGVSC PVMPIKKAPS KKNNKSKSKK GGMTFNVPQP
VHEPIVSHFD SDEEEETAPM SYDEKRQLSL DINKLPGEKL GRVVYIIQSR EPSLRDTNPE
EIEIDFETLK PSTLRELERY VMTCLRKKPR KPYANKKNSA GKSREELALE KQMELERRLM
DVSGQLNSGK KPPKTKRKSC ILLYSVI
//
