ID A0A3Q1AQD2_AMPOC Unreviewed; 802 AA.
AC A0A3Q1AQD2;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Endoplasmic reticulum membrane sensor NFE2L1 {ECO:0000256|ARBA:ARBA00020485};
DE AltName: Full=Nuclear factor erythroid 2-related factor 1 {ECO:0000256|ARBA:ARBA00031659};
DE AltName: Full=Nuclear factor, erythroid derived 2, like 1 {ECO:0000256|ARBA:ARBA00030985};
GN Name=NFE2L1 {ECO:0000313|Ensembl:ENSAOCP00000003473.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000003473.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000003473.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004643}; Single-pass type III membrane protein
CC {ECO:0000256|ARBA:ARBA00004643}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}. Membrane
CC {ECO:0000256|ARBA:ARBA00004183}; Single-pass type III membrane protein
CC {ECO:0000256|ARBA:ARBA00004183}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the bZIP family. CNC subfamily.
CC {ECO:0000256|ARBA:ARBA00008157}.
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DR AlphaFoldDB; A0A3Q1AQD2; -.
DR STRING; 80972.ENSAOCP00000003473; -.
DR Ensembl; ENSAOCT00000009718.1; ENSAOCP00000003473.1; ENSAOCG00000006758.1.
DR GeneTree; ENSGT00950000182892; -.
DR OMA; PEGNQEH; -.
DR OrthoDB; 382726at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd14720; bZIP_NFE2-like; 1.
DR Gene3D; 1.10.880.10; Transcription factor, Skn-1-like, DNA-binding domain; 1.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR004826; bZIP_Maf.
DR InterPro; IPR047167; NFE2-like.
DR InterPro; IPR008917; TF_DNA-bd_sf.
DR PANTHER; PTHR24411:SF31; ENDOPLASMIC RETICULUM MEMBRANE SENSOR NFE2L1; 1.
DR PANTHER; PTHR24411; NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR; 1.
DR Pfam; PF03131; bZIP_Maf; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF47454; A DNA-binding domain in eukaryotic transcription factors; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221};
KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 683..746
FT /note="BZIP"
FT /evidence="ECO:0000259|PROSITE:PS50217"
FT REGION 115..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 355..374
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 211..236
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 802 AA; 88725 MW; E675E6D3E55C3CB5 CRC64;
MLYLKKYFTE GLIQFTILLS LIGVRVDVDT YLSNQLPPLR EIILGPSSAY TQTQFHNLRN
TLDGYGIHPK SVDLDHFFTT RRLLNQVRQL DRLFVPSTEL NTWLVHRDSE TVVSASSQSS
PSITLDNGAG LDDINSPDAT PAMRGGSGAP ESTYNLNAAD SSLGAVAPEG NQEQGNRDGN
DDLTKEDIDL IDILWRQDID LGAGREVFNY SNRQKESEEE KPSPQENKDR NEEQESWRNG
INLQGAQPVD GETGESIPEQ LPGLGSQTSL SLQECLRLLE ATFPFGEETE FPAPVVTSEI
AVSSEEVPST SQGLPLPSQL PSAEPHLDLE QQWQDIMAIM ELQAMEVNNT SLQTTSSSVN
ATSGTTDSNT AGNFELSTRP TPINQDVSLH QASMPSCSQD FPQIFNPQLE SVSITPRTTM
LRLSSSNSTN INSTFGATNL TGIFLPPHIN SSSNNVTSTP ILPDPFSTLL EESMLDEISL
LDLAMEEGFS QAQASQLEDE LDSDSGLSLD SSHSPASPSS SETSCSSAAS SSSTSATFSE
EGAVGYSTDS EVATVETEEG AVGGYQPGYS KLCRMSYQDP SQFHSLPQLD SISHNHTYNL
PLSSAFPERP ELPLSSGKKT VRDKQNSKLQ PPQDLLDKHS SRDERRARAM KIPFSNEKII
NLPVEEFNEL LAKHHLSEAQ LALIRDIRRR GKNKMAAQNC RKRKLDTIIN LEQGVQDLRR
DKARLLKEKM EFIRSIRQMK QKMQSLYQEV FTQLRDEEGR PYPPSEYSLQ YSADGSVLIM
PRGVTTAEQN RKPEKKQKDK KK
//
