ID A0A3Q1AR17_AMPOC Unreviewed; 782 AA.
AC A0A3Q1AR17;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Rho GTPase-activating protein 26-like {ECO:0000313|Ensembl:ENSAOCP00000003713.1};
GN Name=ARHGAP26 {ECO:0000313|Ensembl:ENSAOCP00000003713.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000003713.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000003713.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell junction, focal adhesion
CC {ECO:0000256|ARBA:ARBA00004246}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR AlphaFoldDB; A0A3Q1AR17; -.
DR Ensembl; ENSAOCT00000009317.1; ENSAOCP00000003713.1; ENSAOCG00000007075.1.
DR GeneTree; ENSGT00940000157254; -.
DR OMA; YALITSQ; -.
DR OrthoDB; 5395569at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01249; BAR-PH_GRAF_family; 1.
DR CDD; cd07636; BAR_GRAF; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR004148; BAR_dom.
DR InterPro; IPR035483; GRAF_BAR.
DR InterPro; IPR047234; GRAF_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047225; PH_GRAF.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12552; OLIGOPHRENIN 1; 1.
DR PANTHER; PTHR12552:SF4; RHO GTPASE-ACTIVATING PROTEIN 26; 1.
DR Pfam; PF16746; BAR_3; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 265..369
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 383..567
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 724..782
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 573..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..721
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..140
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 573..591
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..617
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..693
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 706..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 782 AA; 88941 MW; F716ACE62D99A6C2 CRC64;
MGLPALEFSD CYLDSPQFRE RLKSHELELD KTNKFIKELI KDGKALIQAL KSLSTAKRKF
ADSLNEFKFQ CIGDAETDDE MCIAKSLQEF AAVLQNLEDE RTRMIENAND VLIMPLERFR
KEQISAAKEA KKKYDKETEK YCAVLEKHLS LSARKKESHL HEADNQVDNV RQHFYEVSLE
YVFKVQEVQE RKMFDFVEPL LAFLQGLFTY YHHGYELAKD FNHFKTDLTI SIQNTRNRFE
STRSEVESLM RKMKENPHEH KSVSQHTMEG YLFVQEKRSF VSTWVKYYCT YHREPKKVTM
VLFDPKSGGK TGEEESFLLK SCTRRKTDSI EKRFCFDVEA VDRPGVITMQ AMSEEDRRLW
MEAMDGREPV YNLNKDNQAE GMAHLDVIGF NVMKKFIYAV DTRGIDEQGL YRIVGVNSRV
QKLLSLAMDP KTCADVELEN SEWEIKTITS AIKHYLRMLP APLMTYQYQR SFIKAAKMDN
PEARVTEIHA LVHRLPEKNR QMLELLMKHL ANVASHHQQN LMTIANLGVV FGPTLLRPQE
ETVAAIMDIK FQNIVVEILI EHHERIFRDV SNSAGGSANM QLNLSRRRSA ESKAPSCSER
PLTLFHTPTH SQKGEKRNSV VNTADLQQPV SSSANCNSSS SSSSGSSSQS RTPRHSLTSN
DGEQDSRQIR PSSLLNPKSR GSVPTSATSP SPTSPRSPSW PMFSAPSSPQ PTSSASSDSS
PVSIAGRKAR ALYACKAEHD SELSFIAGTI FENVHASREP GWLEGTLDGR TGLIPENYVE
FL
//
