ID A0A3Q1AYL3_AMPOC Unreviewed; 1280 AA.
AC A0A3Q1AYL3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neuronal cell adhesion molecule-like {ECO:0000313|Ensembl:ENSAOCP00000006393.1};
GN Name=NRCAM {ECO:0000313|Ensembl:ENSAOCP00000006393.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000006393.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000006393.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily.
CC L1/neurofascin/NgCAM family. {ECO:0000256|ARBA:ARBA00008588}.
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DR AlphaFoldDB; A0A3Q1AYL3; -.
DR Ensembl; ENSAOCT00000004679.1; ENSAOCP00000006393.1; ENSAOCG00000010166.1.
DR GeneTree; ENSGT00940000155419; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR026966; Neurofascin/L1/NrCAM_C.
DR PANTHER; PTHR44170:SF15; NEURONAL CELL ADHESION MOLECULE; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF13882; Bravo_FIGEY; 1.
DR Pfam; PF00041; fn3; 4.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 3.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..1280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018601595"
FT TRANSMEM 1142..1163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 32..119
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 130..220
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 234..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 327..415
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 421..508
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 512..599
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 616..711
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 713..810
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 815..917
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 921..1017
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1034..1130
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1199..1280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1280 AA; 142683 MW; E59CC3F3C5C98A6D CRC64;
MERRRMEAAL LVLFLGHLVT ALEVPLDLPQ PPTITHQSPK DYIIDPRENI IIHCEAKGKP
HPSFSWTRNG THFDVDNDPN VSMKAHSGTL VVDISREKVE NYEGVYQCTA RNKHGTAVSN
NIVVRQSRSP LWSKEKIKPI VVQEGVSLVL PCRPPAGLPP PIIFWMDNNF QRLPQSRRVS
QSLNGDLYFS NVRREDSRSD YICYARFPHT QTIQQKQPIN VRVLNQAPVD ERRPTFLIPS
GSSSSKMVLR GHVLEMECIA EGLPTPEISW TKVSGDLPAR RTSFLHYNKT LRIVNVSESD
AGDYRCTAKN QLGAVHHTIH VSVKAAPYWI SGPPRNLVLA PRENGVLTCR ASGTPKPSIT
WSMNGIPIEN SPKDVSRKVE DDTIIFTEVQ TGSSAVYQCN ISNDYGYLLS NAFVNVLSEP
PRVLTPANKV YQVIKNHQAL IDCASFGSPI PKITWFKGSR SISLDGDPYI THDNGTLEIH
VAQAQNSGKY TCVARNSLGI YENHVHLEVK EPTRILKQPE YKVVQRGRSV VFECKVKHDP
SLIPTMTWLK DDGELPDDER LIVDSDSLTI TEVTENDAGV YTCIMNTTLD HDSASAELTV
VEATPTPAVV YERPDPPTDL ELTDQKKRSV QLTWTPGDEH NSLIQKFLIQ YEDSLHHRGH
WHNLTEVPGT RTTAHLKLSP YVHYTFRVLA LNAMGFSRPS FPSRMYKTDP AAPDENPTGV
EGFGTEHNNL VISWKPLSGF QANGPGLHYK VMWRQKALDS EWTTVTVANN SKFVVLGTPT
FVPYELKVQA VNNHGDGPEP KIAEGYSGED LPIAAPENVQ AIIVNSTLAE VHWDPVPLHL
IRGHLKGYKV YYWRKHSLHK HNPDHMEKDI LTFSGNHTRG MLPGLHPFSL YSFNVRVYNG
KGEGPPSPTQ QFKMPEGVPG PPSSLLVSNP NLDSLTLEWG PPHDHNGHIT GYTLKYQPVN
NSNELGPVEE VALAANETSI TLPTLKYSTR YKFYLNAKTV TGPGPAITQE VVPIMDEGNT
QTSHPIAWSP PRRPPHKASP FGNVSYAVGE DGALISWEYW GPEKNVYVEY IVKNSEGEEE
WQKELVNGSQ NFMLKGLKEG LSYRVRLVAK GHQDQPLHCS EELLVTVPAV ASRQVDIATQ
GWFIGLMCAI ALLILILLII CFIQRNKGGK YPVKEKEDAH TDPEFQPMKD DDCTFVEYSD
NEDHKPLKGS RTPSNGTVKR DDSDDSLVDY GEGGDGQFNE DGSFIGQYSG KSASRDTAEG
HESSEAPSPI NAMNSLNSFV
//
