ID A0A3Q1B0F8_AMPOC Unreviewed; 1338 AA.
AC A0A3Q1B0F8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=PIK3R4 {ECO:0000313|Ensembl:ENSAOCP00000007270.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000007270.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000007270.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSAOCT00000003125.1; ENSAOCP00000007270.1; ENSAOCG00000011056.1.
DR GeneTree; ENSGT00390000016225; -.
DR OMA; ATNTCRI; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0043226; C:organelle; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd13980; STKc_Vps15; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 26..319
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REPEAT 422..454
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 467..497
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 965..1006
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1305..1338
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 841..860
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1286..1306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..859
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1286..1305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1338 AA; 150001 MW; 8F923808F8945C83 CRC64;
MGNQLAGIAP SQILSVDSYF SDIHDHEYDK SLGSTRFFKV ARAKHREGLV VVKVFAIQDP
SLPLTSYKQE LEELKIRLHS CQNCLPFQKT SLTEKAAILF RQYVRDNLYD RISTRPFLNN
VEKRWLAFQI LNAVDQAHKA GVRHGDIKTE NVMVTSWNWV LLTDFASFKP TYLPEDNPAD
FNYFFDTSRR RTCYIAPERF VDGSMFTTES DQNTPLVDLT NNNQRSRGEL KQAMDIFSAG
CVIAELFTEG VPLFDLSQLL AYRKGLFQTE QVLMKIEDRS IRELVAQMVQ REPEKRLTAE
EYLKQQRGKA FPDIFYTFLQ PYMAQFAKET FQSADERVLV IRKDLDNILH NLRGGSSSSS
SVSQDGSDGM LSSREEQGLI VLVSVITSCL QTLHSCDSKL AALELILHLA PRLGVDILLD
RITPYLLHFC NDPVPRVRAQ AVRTLAKVLA LVKEVPRNDV NIYPEYILPG IAHLAQDDAT
IVRLAYAENI AHLAESALRF LELVQENNVN TEQDLSSEDA EETLHPNENY DSELQALHEM
VQQKVVTLLS DSENIVKQSL MENGITRLCV FFGRQKANDV LLSHMITFLN DKNDWHLRGA
FFDSIVGVAA YVGWQSSSIL KPLLQQGLSD TEEFVIYKAL NALTCMCQLG LLQKPHIYEF
VSDIAPFLCH PNLWIRYGAV GFITVVAQHL NVADVYCKLM PHLNPFITQP IIQINKELVL
LSVLKEPVSR SIFDYALRSK DIASLFRHLL LRQKKRAGSI PECPTPEDPA IAQLLKKLLS
QGMTEAEEDK LLALKDFMLK SNKAKANMGE QSHLGEAVQT GVIDLATLGI TGRQVDLVKP
KAEAEDKRAR KHTKQDSTMN EEWKSMFGSQ EPPSSQAVTA TDGPVSQIRK SAVAPAVPVL
QSVASGPAYQ RRINTCKAEL QQLVQQKREQ CSAERMAKHM MESAEWESRP PPPGWHPKGL
LVAHLHEHKA AVNRIRVSDE HSIFATASND GTVKVWDSQK MEGKTTTTRS VLTYSRIGGH
VKTLTFCQGS HYLAVASDNG SIQLLAVEAN KPPKSPKVQP FQTRSLDLQE DGCAVDIHHF
NSGAQSVLAY ATVNGSLVGW DLRSNSNAWT LRHDLRLGLI TSFTVDMHQC WLCLGTSSGT
MACWDMRFQL PISNHSHPAR ARIRRLLMHP LYQSSVIAAV QGNNEVSMWD METGDRKFTL
WASSAPPLSE MQPSPHSVHG IYCSPADGNP LLLTAGSDMR IRFWDLAYPE RSYIVAGGAN
DSLHCPSVLY SRKIIEGTEV VQEIHSKQKS GVVEDSPRRG PESLPVGHHD IITDIATFQT
TQGFIVTSSR DGIVKVWK
//
