ID A0A3Q1B2F3_AMPOC Unreviewed; 722 AA.
AC A0A3Q1B2F3;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000007698.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000007698.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR AlphaFoldDB; A0A3Q1B2F3; -.
DR Ensembl; ENSAOCT00000002374.1; ENSAOCP00000007698.1; ENSAOCG00000011642.1.
DR GeneTree; ENSGT00940000157987; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13284; PH_OSBP_ORP4; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972:SF194; OXYSTEROL-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 14..106
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 242..274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 644..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 292..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..673
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 722 AA; 82749 MW; 151633C64CB990CD CRC64;
SSRPLTPDPP PSRSDTYKGW LFKWTNYLKG YQRRWFVLSN GLLSYYRTQA EMAHTCRGTI
NLATAHIDTE DACNIVLSSG GRTYHLKAST EVERQRWVTA LELAKAKAIR MMNDQSGDEE
PTSQSDRSEI QGTLKILVSK LDDLSTCNDL IAKHGAALQR SLSELEGLKV PVEGGEKIKA
VNERATLFRI TSNAMINACR DFLDLAETHS RRWQRALQYE REQRTHLEET IEQLAKQHNS
LERAWREAPT LVSSTPRSER SRKEEASDED EDTEYFDAME DSPAFITVTA SENTQHRSMS
PSCNDVSGKE LQPRRQRRTH IPDKPNYSLN LWSIMKNCIG KELSKIPMPV NFNEPLSMLQ
RLSEDLEYHE LLDKAARCDS SLEQMCLVAA FSVSSYSTTV HRTAKPFNPL LGETYELDRL
EEFGYRSLCE QVSHHPPAAA HHVISQRGWT LWQEITIASK FRGKYLSIMP LGAIHLHFHA
SGNHYVWRKV TSTVHNIIVG KLWIDQSGDI EIVNHRTKET CQLKFSPYSY FSRDVPRKVT
GVVADSGGQA HYILSGTWDE KMESSKIVQS SRGGSGSEGK QKTVYQTLSP KLLWKKYPLP
ENAENMYYFS ALALTLNEPE EGIGLTDSRL RPDQRLMEDG RWDEANSEKQ RLEEKQRAVR
RRREAEASDA LDEGMKQRTG SYQPLWFHQR RDSITGETNF VYKGGYWESK DRQDWSMCPD
IF
//
