ID   A0A3Q1B4C6_AMPOC        Unreviewed;       721 AA.
AC   A0A3Q1B4C6;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Cyclic nucleotide gated channel subunit alpha 3 {ECO:0000313|Ensembl:ENSAOCP00000008373.1};
GN   Name=CNGA3 {ECO:0000313|Ensembl:ENSAOCP00000008373.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000008373.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000008373.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q1B4C6; -.
DR   STRING; 80972.ENSAOCP00000008373; -.
DR   Ensembl; ENSAOCT00000001216.1; ENSAOCP00000008373.1; ENSAOCG00000012372.1.
DR   GeneTree; ENSGT00940000158737; -.
DR   OMA; ECEPQTR; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.20.5.300; -; 1.
DR   Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR032406; CLZ_dom.
DR   InterPro; IPR018488; cNMP-bd_CS.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   PANTHER; PTHR45638:SF6; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3; 1.
DR   PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR   Pfam; PF16526; CLZ; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SMART; SM00100; cNMP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR   PROSITE; PS00888; CNMP_BINDING_1; 1.
DR   PROSITE; PS00889; CNMP_BINDING_2; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
PE   4: Predicted;
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        338..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        410..433
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          514..628
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   REGION          101..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   721 AA;  83471 MW;  09E79CB4E39D5C70 CRC64;
     MAKVGSEKSF SARQRLSTNT SDDELAVIEN GDSRFDISII SREIFLPHHC IVDYVLQSPS
     LVVGLSYFFF MLRTWASHRM NPEEERHDSF LERFRGPELK DMSCRESNAQ SVGPDDTLRK
     RNKKEEIKKD DKKEEEKKDE KKNEDEKKDG DKKEEEKKDE KKDEKKDEKK DDKKDDKKDD
     KKKEEPPKEI WIMDPAADQY YKWLSVIAGP VFYNLMMIVT RACFNELQDS YTKLWLVLDY
     TSDAIYYADT FVRSRTGYLE QGLLVKDSKK LREKYRTTSQ FKYDIISMIP TDLLFLKYGY
     NNPEFRFNRL CKISRLFEFF ERTETRTSFP NMFRISNLVL YILVIIHWNA CLFFAISKTI
     GFGSDTWVYP NISHPEHGRL ARKYIYSLYW STLTLTTIGE TPPPVRDVEF LFVIADFLTG
     VLIFASIVGN VGAMISNMNA SRAEFQAKID SIKQYMQFRK VTKDLEARVI KWFDYLWTEK
     KTCDEKEVLK NLPDKLKAEI AINVHLDTLK KVRIFQDCEA GLLIELVLKL QPQVFSPGDY
     ICKKGDIGRE MYIIKEGKLA VVADDGVTQF VVLSDGAYFG EISILGIKGS KAGNRRTANI
     RSVGYSDLFA LSKDDLMEAL TEYPEAKKAL EEKGKAILMK DNLIDEAIAN AGADPKDMEE
     KIVKLQSNLD TMQVKFAQLM AEFTSNQTRM KQRVTNMEAK VKSLRPEDLT EVMADKDKKV
     Q
//