ID A0A3Q1B614_AMPOC Unreviewed; 352 AA.
AC A0A3Q1B614;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Beta-2-glycoprotein 1 {ECO:0000256|ARBA:ARBA00020104};
DE AltName: Full=Apolipoprotein H {ECO:0000256|ARBA:ARBA00029855};
DE AltName: Full=Beta-2-glycoprotein I {ECO:0000256|ARBA:ARBA00033414};
GN Name=APOH {ECO:0000313|Ensembl:ENSAOCP00000009617.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000009617.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000009617.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Binds to various kinds of negatively charged substances such
CC as heparin, phospholipids, and dextran sulfate. May prevent activation
CC of the intrinsic blood coagulation cascade by binding to phospholipids
CC on the surface of damaged cells. {ECO:0000256|ARBA:ARBA00003651}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR AlphaFoldDB; A0A3Q1B614; -.
DR STRING; 80972.ENSAOCP00000009617; -.
DR Ensembl; ENSAOCT00000016403.1; ENSAOCP00000009617.1; ENSAOCG00000013757.1.
DR GeneTree; ENSGT00940000157228; -.
DR OMA; QRYFNPG; -.
DR OrthoDB; 4131542at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 4.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR015104; Sushi_2.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR19325:SF549; BETA-2-GLYCOPROTEIN 1; 1.
DR PANTHER; PTHR19325; COMPLEMENT COMPONENT-RELATED SUSHI DOMAIN-CONTAINING; 1.
DR Pfam; PF00084; Sushi; 4.
DR Pfam; PF09014; Sushi_2; 1.
DR SMART; SM00032; CCP; 4.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR PROSITE; PS50923; SUSHI; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Heparin-binding {ECO:0000256|ARBA:ARBA00022674};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..352
FT /note="Beta-2-glycoprotein 1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018742902"
FT DOMAIN 25..85
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 86..143
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 144..206
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 207..266
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DISULFID 27..70
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 114..141
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 209..252
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 352 AA; 39548 MW; 07D13BFE81847E4A CRC64;
MERMLTLFLL CPALFFTTVT SQRDNVCLRP NLADTIEMAG LQRYFNPGVE LALSCIDGYT
PVLGPRKIVC TVSGEWTKTR FLCTPKRCPY PDPLPNGELY YEDTIYQSTI NYTCNEGYVL
TGSSTSVCQA NGTWSTLVPE CTPVTCDLAP IPQFGMIIYD TTVRGNITYY GTTGMYRCHP
PYALIGNPRA ECTASGTWTK TPECKVVTCH PPHNIARGYM STTDQRDFDY METVKYGCTG
DFVLEGSQEI VCQQDGNWSE KPSCKAPCEV SINRGRILYK GRRIWIKDFE PNKVLHKEIV
SVYCKNAARK CGYAVPTQCI DGRLQIPECF KEPSYADYNF HSSSLPSEIT QC
//
