ID A0A3Q1B9J0_AMPOC Unreviewed; 2018 AA.
AC A0A3Q1B9J0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha-1A {ECO:0000256|ARBA:ARBA00039688};
DE AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.1 {ECO:0000256|ARBA:ARBA00041622};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000006671.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000006671.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003808}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003808}.
CC -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit (TC
CC 1.A.1.11) family. CACNA1A subfamily. {ECO:0000256|ARBA:ARBA00037936}.
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DR Ensembl; ENSAOCT00000004166.1; ENSAOCP00000006671.1; ENSAOCG00000010481.1.
DR GeneTree; ENSGT00940000156518; -.
DR OMA; AFRMIRV; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 4.
DR Gene3D; 6.10.250.2180; -; 1.
DR Gene3D; 6.10.250.2500; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR031649; GPHH_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014873; VDCC_a1su_IQ.
DR InterPro; IPR002077; VDCCAlpha1.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR45628; VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR45628:SF3; VOLTAGE-DEPENDENT P_Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1A; 1.
DR Pfam; PF08763; Ca_chan_IQ; 1.
DR Pfam; PF16905; GPHH; 1.
DR Pfam; PF00520; Ion_trans; 4.
DR PRINTS; PR00167; CACHANNEL.
DR SMART; SM01062; Ca_chan_IQ; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 4.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PIRSR:PIRSR602077-1};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU003808};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU003808}; Coiled coil {ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|PIRSR:PIRSR602077-3};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR602077-1};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003808}.
FT TRANSMEM 64..86
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 200..219
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 401..427
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 824..842
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 862..882
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 894..912
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..978
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1068..1093
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1149..1168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1180..1202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1259..1288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1360..1384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1522..1556
FT /note="Voltage-dependent calcium channel alpha-1 subunit
FT IQ"
FT /evidence="ECO:0000259|SMART:SM01062"
FT REGION 528..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 584..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 771..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1552..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1620..2018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 423..459
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 540..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1606
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1640..1659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1662..1685
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1699..1722
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1735..1750
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1785..1812
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1850..1865
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1872..1897
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1920..1939
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1964..1979
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 45
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 380
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT BINDING 1039
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-1"
FT CARBOHYD 10
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR602077-3"
SQ SEQUENCE 2018 AA; 230503 MW; 49F0F2519FF8474F CRC64;
NELPSRLCPN GTVCRKGWLG PNYGITQFDN ILFAVLTVFQ CITMEGWTDM LYYSNDVEGS
AWNWMYYIPL IIIGSFFMLN LVLGVLSGEF AKERERVENR SEFLKLRRQQ QIERELNGYL
EWICKAGQCS LTNTHCRRRP TIKTKNNKTE LLNPEEGEDN MGDAVGFARS SIKSGKDGSS
YSKKERRMRF FIRKIVKTQA FYWTVLCLVG LNTICVAAVH YNQPELLSDF LFYAEFIFLG
LFMSEMLIKM YGLGIQPYFH SSFNCFDCVV IVGSIFEVVW ATIKPGTSFG ISVLRALRLL
RIFKVTKYWA PLRNLVVSLL NSMKSIVSLL FLLFLFIVVF ALLGMQLFGG QFNFEGGTPP
TNFDTFAAAI MTVFQILTGE DWNVVMYDGI ESQGGVNDKG MVFSIFFIVL TLFGNYTLLN
VFLAIAVDNL ANAQELTKDE EEQEEAANQK TALQKAKEVA EVSPLSAANL SIAAKEQQKN
HTKGNKSVWE QRTSEIRRQN LMTSREALYN ELEQDDWKVS YPRKARGDMK THLDRPLVVN
PQDNRNNNTN KTQPGELPLD QEYQRQDIDH CRRAAHYYHY HHRPHQNAIG PHSARSVSPH
HSEGMQGNNE HRRSRQHRRA AREGEEGRRH RSRGTEGEGD RGEDGEGRKT RRHRHGNQER
SRGHRMRNTG PNLSTTRPIQ QYNEDLDNFR NNSKLASAHE HPYALPPDHP DHPDHVNNLL
NCRDADTHTL LHSMDSLILT SMAKPEYTTI DMPPVYPYPS TNAILQVNKN ANTDQKKSEE
KKEEEDEGGD EDGPKPMPPY SSCFIMSTTN PFRKCCHYIL TLKYFEFSIL SVIAMSSIAL
AAEDPVWPDS PQNNVLRYFD YVFTGVFTFE MLIKMVVLGL FLHQGSYFRD LWNILDFIVV
SGALVAFAFT GSSKGKDIST IKSLRVLRVL RPLKTIKRLP KLKAVFDCVV NSLKNVLNIL
IVYMLFMFIF AVVAVQLFKG RFFFCTDESK EFERDCRGEY LVYDREKVEA QKREWKKYDF
HYDNVAWALL TLFTVSTGEG WPQVLKHSVD STYENQGPSP GYRMEMSIFY VVYFVVFPFF
FVNIFVALII ITFQEQGDKM MEDYSLEKNE RACIDFAINA RPLTRHMPKN KLSFQYRMWQ
FVVSQPFEYS IMALIALNTI VLMMKFDGAS DTYNDVLKNL NIVFTTFFFM ESVLKIIAFG
PLNYFRDAWN IFDFVSVLGS ITDILVTELG NNFINLSFLR LFRAARLIKL LRQGETIRIL
LWTFVQSFKA LPYVCLLIAM LFFIYAIIGM QLFGNLALDE EGESAINEHN NFRTFIMALM
LLFRSATGEA WHEIMLACLG GKECDPASGN TEPECGSTFA YTYFVSFIFL CSFLMLNLFV
AVIMDNFEYL TRDSSILGPH HLDEYVRIWA EYDPAACGRI HYKDMYSLLR VISPPLGLGK
KCPHRVACKR LLRMDLPVAD DNTVHFNSTL MALIRTALDI KIAKGGADKH QMDAELRKEM
MAIWPNLSQK TLDLLVTPHK AATDLTVGKI YAAMMIMEYY RQSKTKKLQA LREEQNRPPL
MFQRMKPPSE GGGTDVQGGQ GQNGLPSTQP DNMNSIPPEG GMTESQSWMT TKAQEMFQKT
GNWSPDRPYP DDPHDNRHNP QTITDTSPMH RSTSSLVHGR SGRGVRLDDY SLERVVSEEG
RHGGGRRHRE RSHRTSQRSL TRYTDADTGL GTDLSTTTQS GDLPPKEHER DRGRTKDRRH
HHHHHHHHSS MDKEHYGPDR HDYPHRHPHD RHWSRSPSEG PDGRGPRQGS SSVSGSPVPS
TSGTSTPRRG RRQLPQTPAV PRPHVTYSPA VRKPSYGPPG PGRLRSPSPR HFSPPDHDRG
YHHRPPSRHA SPHHGGSSSR HGSPHSPRHQ SPRSPLHGSP RSPHRSRWSG PPPGDSLEGD
GPFYERDYEY ERHHEPPAYE QSLSHGNPHP HGGNPHPHPR SPRTARHGPP PPPHPHPRRV
PNGYRSSSPS PHRRGPPGAG PRKGLHEPYS ETDEDDWC
//
