ID A0A3Q1B9L0_AMPOC Unreviewed; 912 AA.
AC A0A3Q1B9L0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Toll-like receptor 13 {ECO:0000313|Ensembl:ENSAOCP00000006696.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000006696.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000006696.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
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DR AlphaFoldDB; A0A3Q1B9L0; -.
DR STRING; 80972.ENSAOCP00000006696; -.
DR Ensembl; ENSAOCT00000004111.1; ENSAOCP00000006696.1; ENSAOCG00000002101.1.
DR GeneTree; ENSGT00940000161095; -.
DR OMA; YNNRLHF; -.
DR OrthoDB; 1207361at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365:SF541; MSTPROX-RELATED; 1.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00365; LRR_SD22; 6.
DR SMART; SM00369; LRR_TYP; 13.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..912
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018551389"
FT DOMAIN 748..893
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 912 AA; 103846 MW; C2A23EECBD117EC9 CRC64;
MVRTVLFLLL LHTSACWGFG FKGCSQNFPK TDTMWCFNQN IVNLSDVISM IPDNVTTINL
SKNKIRVIPV GSFSRLTGLR HLDLSQNELV SLKRGVFRGL DYLDCLNLTC NNISHINPTA
FEGLTRLQTL FLTHNTLLLI HPAVFDVLLA IQRVDLSLNV LKSFDCGRSG GSSTLKHLDL
FANNIQKLNV SCFPALEYIR LSNNTEMQLP ADVFASNPKL KTLLLQGVKA ELVVGLSTQT
KRNLSWLSVS LFLDKPPWTI CELLRGMDKL EKIEVDLKGS KLPQRNSSLL DCKLPQVVAI
LDANFGNVAQ LSLGKGNTSR LDLINCGLRQ ISHATFEGFR RLKTLQLNQN NIVLQQDTFK
GLTHLTFLSF DRNKIHELDP NWFIPLKRLT RLSLLKNQIT ELTPNVFSAL TQLEQLYLQF
NLLKYITKKP FSKLRKLTKL NLSLNIIDFI EEGSFQDLTN LRYLDLSGNR IKRLTPPILS
GLINLRKFVL YNNRLHFRSY ETPFINLPSL EYLEMNYQGP GGQGIGNIGP NFFQGQHRLS
HIAIGHSIMM NIHPDAFVPL VNLTQLYIAG VVMKTTNLTA VLLPLKRLKK LTLYRADLDV
LPANLLPPNN TLEILKVQAN HIHTVDKDLL DALPRLRVLD VTENPLSCIC DNSWFKTWAI
NNDHTQVSYL YNLRCDNGRR SSYLWQFDDK ACSYEQVSFT LFITCSVIDV LLVCVCLSWQ
TQGPALRYLL LIVRAKLRGR RGVEGAKYQY DAFVSYSSKD EAWVMGQLVP NLENPAAGAA
RLRLCLHHRD FRPGTAVLEN IEAAIYSSRH TICVVTRHFL QSEWCSVEFQ LASLRLLCDG
SDVLLLLFLE EIPEHCLSPY TRLRKIVRRK TYLLWPEEPQ EQDAFWVRLI DALKGNEEEE
EGGEEELARL IE
//
