ID A0A3Q1BAE4_AMPOC Unreviewed; 810 AA.
AC A0A3Q1BAE4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Toll-like receptor 2 {ECO:0000256|PIRNR:PIRNR037595};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000010990.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000010990.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Cooperates with LY96 to mediate the innate immune response to
CC bacterial lipoproteins and other microbial cell wall components.
CC Cooperates with TLR1 or TLR6 to mediate the innate immune response to
CC bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6,
CC leading to NF-kappa-B activation, cytokine secretion and the
CC inflammatory response. {ECO:0000256|PIRNR:PIRNR037595}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634, ECO:0000256|PIRNR:PIRNR037595}.
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DR AlphaFoldDB; A0A3Q1BAE4; -.
DR Ensembl; ENSAOCT00000030056.1; ENSAOCP00000010990.1; ENSAOCG00000015496.1.
DR GeneTree; ENSGT00940000156323; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-UniRule.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-UniRule.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:UniProtKB-UniRule.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF17; TOLL-LIKE RECEPTOR 2; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF01582; TIR; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859, ECO:0000256|PIRNR:PIRNR037595};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588,
KW ECO:0000256|PIRNR:PIRNR037595};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR037595};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 597..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 656..803
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 810 AA; 91524 MW; 5C0C8050A83082B6 CRC64;
GKTFFKLYFT RIVKLRSDSG DGRSDSGDGR SSCNRCDSHL SCNCSHGGFT HIPVVTDRAL
TIDLSCNAIA TVMDDDLMGH TRLRALDLHG NGLAAIQPSA FDSLWSLEEL DLSDNQLAAL
NYRWFRKLEA LQQLNLLSNP YSCLGSPPLF QGLVRLRRLA FGGPALEELR RGDLSGVTQL
EELTVHANNL TRYELGTLAD IWPLGRVTLS LHGPFLTNMP VASAVLGDVS YPETPITLED
LHLIGNWSVQ PLRESARKRI RHLSFRNLSV SDEAVVSLLV VVDGVPITFL SVDGITLTGE
GRWVKASYTD QRSIDEFFAQ DVVVLDVFKF FSLLDLKFLL QYLRRVSVIN SKVFVMPCIT
SKLLVNLQYL DLSDNLLTDL TLVETLCGDH ETLKELRVLN ISGNPLKSLS TVSRLVMKLS
KLTHLDVSRT GYISMPPSCP WPSTLRHLNI SGAKLTTTTP CLPATLEVLD LSNNNLRGFT
QHLPVLRELH LSGNKFLSLP PGQLFPNLQT LTIHSNTLNM FGRLDLQSFR RLESLQAGQN
QFVCSCDFVN FLQSALKGHE GIHLTDGEDN YVCDSPLYLQ GEPVGRVHLS IVTCHRVLFV
SVSCGLVLVV GVLLGVLLWR LHAFWYLKMT WAWLKAKHSS RRRQRHRVIE GSEALLSFDA
FVSYSERDAG WVENFLVPEL EEPRTSRSLT LCLHKRDFLP GHWIVDNIMS AMERSRRTVF
ILSENFVQSD WCRYELDFSH FWLFDGHAGG EAAILVLLEP LSKDDVPKRF YKLRKLMSST
TYLEWPREEE RRPEFWRSLR KALRGGDEDD
//
