ID A0A3Q1BGM8_AMPOC Unreviewed; 793 AA.
AC A0A3Q1BGM8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sodium/hydrogen exchanger {ECO:0000256|RuleBase:RU003722};
GN Name=SLC9A1 {ECO:0000313|Ensembl:ENSAOCP00000013295.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000013295.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000013295.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC transporter (TC 2.A.36) family. {ECO:0000256|ARBA:ARBA00007367,
CC ECO:0000256|RuleBase:RU003722}.
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DR AlphaFoldDB; A0A3Q1BGM8; -.
DR Ensembl; ENSAOCT00000021390.1; ENSAOCP00000013295.1; ENSAOCG00000017863.1.
DR GeneTree; ENSGT00940000156338; -.
DR OMA; TIMTYAV; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR GO; GO:0006885; P:regulation of pH; IEA:InterPro.
DR Gene3D; 6.10.140.1330; -; 1.
DR Gene3D; 6.10.250.1040; -; 1.
DR Gene3D; 6.10.250.2020; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR004709; NaH_exchanger.
DR InterPro; IPR001970; NHE-1-like.
DR InterPro; IPR032103; NHE_CaM-bd.
DR NCBIfam; TIGR00840; b_cpa1; 1.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF196; SODIUM_HYDROGEN EXCHANGER; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF16644; NEXCaM_BD; 1.
DR PRINTS; PR01084; NAHEXCHNGR.
DR PRINTS; PR01085; NAHEXCHNGR1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU003722};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003722};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003722};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003722}.
FT TRANSMEM 21..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 141..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 276..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..385
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 433..452
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 464..487
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..488
FT /note="Cation/H+ exchanger"
FT /evidence="ECO:0000259|Pfam:PF00999"
FT DOMAIN 584..688
FT /note="Sodium/hydrogen exchanger regulatory region"
FT /evidence="ECO:0000259|Pfam:PF16644"
FT REGION 45..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 87815 MW; 9F95007F12DB4AB6 CRC64;
MPSRTGSHSP AGFGKSLPER GLLLLMVLVF LEGSVLPLGA ASSPDTSHQT NLGDHQGTHT
GPNSTKKPFP VLAVEYDRVQ IPFEISLWVL LASLMKLGFH LIPRLSSIVP ESCLLIVVGL
LVGGLIKLAG EEVPPVLDSR LFFLCLLPPI ILDAGYFLPI RPFMENLGTI LMFAVVGTLW
NAFFIGGVLY GVAQIQPANP SDLHQLELLP CLLFGSIISA VDPVAVLAVF EEIHINELLH
ILVFGESLLN DAVTVVLYHL FEEYAGVGTV TLLDGVLGVI SFFVVALGGV LVGAIYGILA
AFTSRFTSHT RVIEPLFVFV YSYMAYLSAE IFHLSGIMAL IACGAVMRPY VEANISHKSH
TTIKYFLKMW SSVSETLIFI FLGVATVDGP HAWNWTFVTV TVILCLVARV IGVVGLTYVI
NKFRIVKLTT KDQFIIAYGG LRGAIAFSLG FLLNQDHFPM RKMFLTAIIT VIFFTVFVQG
MTIKPLVELL AVKKKQEAKR SINEEIHTQF LDHLLTGIED ICGHYGHHHW KDKLNRFNKK
YVKKCLIAGE RSKEPQLIAF YHKMEMKQAI ELVESGGGVK LPSAMPSTVS MQNIQPKKPP
PAKPVERVLP QLPKGREEEI RKILRSNLQR TRQRLRSYNR HTLVADPYED GFSDLLIKKQ
RMVELEKKIK EMSNYLTVPA APPDSPTMCR ARLASDPQAY SMKPVSDSVP TIQVDLASPQ
SPDSVNLLDE FRHAGQQQPE VEDQGLMMKP PSGPSGPNKP READEARDQQ KLMRCLSDPG
PSADEDEDEP FLP
//
