ID A0A3Q1BH53_AMPOC Unreviewed; 529 AA.
AC A0A3Q1BH53;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
GN Name=GDF10 {ECO:0000313|Ensembl:ENSAOCP00000011899.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000011899.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000011899.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; A0A3Q1BH53; -.
DR STRING; 80972.ENSAOCP00000011899; -.
DR Ensembl; ENSAOCT00000019465.1; ENSAOCP00000011899.1; ENSAOCG00000016264.1.
DR GeneTree; ENSGT00940000157214; -.
DR OMA; TFHFLFD; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..529
FT /note="Growth/differentiation factor 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018688555"
FT DOMAIN 414..529
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 243..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..283
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 529 AA; 60187 MW; BC09C3664B19641A CRC64;
MAVLSMISSH LLLLMINCFL GAASVRTVTV DSRFHQSSSD PDDLDQDMVY QHMHRLYEKY
NKENRLKEGN TVRSFKASQE SSDRRMMYRL NLTTLQDSEV ILSATFHFLL DKHSHHKPWF
CKRFKSPSCR SSDIHPSPSV SLLLRSVSSG SEVRSGSMGS FLGNVTFHPH RRGVWQMKDV
TQVIKEARDK GHLLVSVELD LRKQYQKKPE ETLSAGSMPY LLLYANDQAL AEPNSVAASL
QRYDPFSEGG DTSHSSQASQ LLHRPNSSPE LKGRVRREAN LHSDPIQNNE LPEVDYRPDG
YRKDDLWEST WYLALKPKPK SGRKEQKRKS HEEEGAESKQ VHEPQVLKEG ERTSQEIKTD
DSTVTKLKDS RTQTVSDMQK HERRNEGKDG KKHKGSVNAQ SPVLSFDEQT MRKARRRQWS
SNQHRGCSRR NLRVDFADIG WSEWVIAPKA FDAYYCAGTC GFPMPKVTRP SNHATIQSIV
RAVGIIPGVP EPCCVPESMS PLAVLYQDES RNPVLKIYPN MSVQSCSCR
//
