ID A0A3Q1BHN8_AMPOC Unreviewed; 1247 AA.
AC A0A3Q1BHN8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Caskin-2-like {ECO:0000313|Ensembl:ENSAOCP00000012144.1};
GN Name=CASKIN2 {ECO:0000313|Ensembl:ENSAOCP00000012144.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000012144.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000012144.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; A0A3Q1BHN8; -.
DR Ensembl; ENSAOCT00000019782.1; ENSAOCP00000012144.1; ENSAOCG00000016582.1.
DR GeneTree; ENSGT00940000158256; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR CDD; cd09497; SAM_caskin1_2_repeat1; 1.
DR CDD; cd09498; SAM_caskin1_2_repeat2; 1.
DR CDD; cd12063; SH3_Caskin2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR InterPro; IPR033635; ANKS1/Caskin.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR032232; Caskin1-CID.
DR InterPro; IPR035497; Caskin1/2_SAM_1.
DR InterPro; IPR035498; Caskin1/2_SAM_2.
DR InterPro; IPR035499; Caskin2_SH3.
DR InterPro; IPR032117; Caskin_C.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR24174; ANKYRIN REPEAT AND STERILE ALPHA MOTIF DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR24174:SF19; CASKIN-2-LIKE-RELATED; 1.
DR Pfam; PF12796; Ank_2; 3.
DR Pfam; PF16907; Caskin-Pro-rich; 1.
DR Pfam; PF16632; Caskin-tail; 1.
DR Pfam; PF16600; Caskin1-CID; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00454; SAM; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 5.
DR PROSITE; PS50088; ANK_REPEAT; 5.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT REPEAT 48..80
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 81..113
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 114..146
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 188..220
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 220..252
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 281..347
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 448..511
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 517..581
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 348..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 767..1130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..698
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 778..798
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..850
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 948..962
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..995
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1019..1058
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1064..1096
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1098..1112
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1247 AA; 134185 MW; 8C8CC5C1F88D11A6 CRC64;
MGKEQDLLQA VKSGDLLSTQ KLLSKLKTNR NKLLGSTKRL NVNFQDCDGF SALHHAALTG
TSELLSALLE AQATVDIKDS NGMRPLHYAA WQGKAESVLM LLRSGASVNG VSLDGHIPLH
LAAQYGHFEV SEMLLQHQSN PCLVNKAKKT PLDLACEFGR VKVAQLLLSS NMVVALLEGE
RKEPTDSAFT TPLHLAARNG HKDIIRLLLK AGIDINKTTK SGTALHEASL YGKTEVVRLL
LDAGVDVNIR NTYNQTALDI VNQFTTSHAS KDIKQLLRDA TGVLQVRALK DYWNLHDPTA
LNIRAGDVIM VMEQHVDGRW KGHIHDSQRG MDRVGFFPPS IVEVISRRNA GDRNSVGSTG
SVGSTRSAGS GQSTESNHAA NGLHHNTGHH DNKAAPPAVD AGHSADLNKQ PDHPAGGTPR
RPTVTVQRPA EQSFSQQFVR PQQLLEGKDA EAIYQWLSEF QLEQYIGNFL NAGYDVPTIS
RMTPEDLTAI GVTKPGHRKK ISIEINNLNI PEWLPEYIPS DLGEWLSAIG LPQYHKKLAE
NGYDSISIVK DLTWEDLQEI GITKLGHQKK LMLAVKKLCD IQRAILQAES GQGTLRRKGP
GALHLVAIEP PDSGGECSSP HTPKMLTFQD SELSAELQTA MSSHYSGCEE GLAIKNAVGM
SQSQESIDTR SRGSGRSQDP PTASINPHSW SQESLEGSPA KERNLPEGWD QRPLQQQPLP
KQVPLGTATV FKYPAIPAKP KLSGSRGNSP HGSPALKGFS YLHSHCGSTD LRSSHRSENH
TMTLTPPKKR TQNMTRYALS DGEPEEDDEE LAVPPGNVPS YATLTRKPGR SQLARLQSSP
EKNGNVGRSQ SFAVRARKKG PPPPPPKRLS SVSSTTSGEL SDSSTTSSSG GVVTDSPGSV
RSIAASLESG TEGNNSPGHK PDLVQQEPHS FSSAEPREAV GLRRRVQSEC VPTQTCSSTE
LDRGVKSDSE EEDSKGRGLE GSSSPQNSSS ECIPFAEEGN LTIKQRPKAP GPPRAEAVLE
PPDKQEDKNL DVPEFNLKES DTVKRRHKPK DKEQGEGSPC REGTGSGSGR SRPPSQSQEE
VSLRISEASL ERPSSPATGS PIKPPLSPKP AVAPKPVRHS LLAAQRPSSP TVTISVVQSV
AFASPSSPAH RPPASASAPQ SPSLAAARPQ VCVVGLGHLH EESEVVQQRL DQTSTSLAAA
LMAVESKLSL DDSSEGSVST VKSAGTILDD IGNMFDDLAD QLDAMLD
//
