ID A0A3Q1BI44_AMPOC Unreviewed; 574 AA.
AC A0A3Q1BI44;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Frizzled class receptor 9b {ECO:0000313|Ensembl:ENSAOCP00000009121.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000009121.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000009121.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR AlphaFoldDB; A0A3Q1BI44; -.
DR STRING; 80972.ENSAOCP00000009121; -.
DR Ensembl; ENSAOCT00000029298.1; ENSAOCP00000009121.1; ENSAOCG00000013235.1.
DR GeneTree; ENSGT00940000161226; -.
DR OMA; CEGIGYN; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd07463; CRD_FZ9; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041777; FZ9_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF79; FRIZZLED-9; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 219..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 255..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 388..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 436..457
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 492..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..145
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 219..521
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 140..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 29..90
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 37..83
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 74..112
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 101..142
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 105..129
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 574 AA; 64269 MW; 80146AA585347201 CRC64;
TQRPPSSSSS SCLFEIGSYD LERGRPAKCE PIVIPMCEGI GYNLTRMPNF MDHDDQKEAA
IKLQEFAPLV AYGCDVHLRF FLCSLYAPMC TDKVSTSIPA CRPMCEQARE RCAPIMKKFS
YTWPDSLDCS KLPTRNDPNA LCMEAPENET RTEGKKGEGM LPVPPRPRQP GTNSGRSPGS
MGSCENPDKF QFVEKSQSCA PRCSPAVDVF WSRQDKDFAF IWMTVWSILC FVSTAFTVLT
FLLEPHRFQY PERPIIFLSM CYNVYSVAFI IRSVAGAENI ACDREHGELY IIQEGLESTG
CTIVFLILYY FGMASSIWWV ILTLTWFLAA GKKWGHEAIE AHSNYFHMAA WGIPALKTII
ILTMRKVAGD ELTGLCYVGS MDSGALTGFV LIPLSCYLII GTSFILTGFV ALFHIRKVMK
TEGTNTEKLE KLMVKIGIYS ILYTVPATCV IVCYFYERLN MDYWKLRGLQ MKCGSFNGHS
SDCSLQTSVP TVAVFMLKIF MSLVVGITSG VWVWSSKTLQ TWQGLCSRKL ADRTSSRKPC
SGVSCGSMHC HYKSPAVVLH MAKTDLHSDN PTHV
//
