ID A0A3Q1BIH0_AMPOC Unreviewed; 996 AA.
AC A0A3Q1BIH0;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Rap guanine nucleotide exchange factor 4-like {ECO:0000313|Ensembl:ENSAOCP00000014010.1};
GN Name=RAPGEF4 {ECO:0000313|Ensembl:ENSAOCP00000014010.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000014010.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000014010.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RAPGEF2 family.
CC {ECO:0000256|ARBA:ARBA00010829}.
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DR AlphaFoldDB; A0A3Q1BIH0; -.
DR Ensembl; ENSAOCT00000022203.1; ENSAOCP00000014010.1; ENSAOCG00000018697.1.
DR GeneTree; ENSGT00940000156075; -.
DR OMA; LYCYVLE; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 44..147
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 212..287
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 352..453
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 492..626
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 663..699
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 767..994
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 996 AA; 114056 MW; 0564EDCAC40A9A2D CRC64;
MVAAHTSSHS SESAEWIICL DKRPAERSGE DVDIILARLK NVKAFERFHP SLLQQICLCG
FYECLEKGIT LYRQGDIGTS WYAVLSGSLD VKVSETSSYQ DAVTICSLGT GTAFGESILD
NTPRHATIVT REFSELLRIE QREFRSLWEK YHHCMAGLLA PPYGVMESSA DRMPDKENIS
NNSFVSVSKH QNKVPSEKLL RAGKVLRNAI LSRAPHMIRD RKYHLKTYRQ CCVGTELVDW
QMQQSSCVHS RVQAVGMWQV LLEEGVLNHV DHELSFQDKY LFYRFLDDEQ EDAPLPSEEE
RKESQEELQD TLLLLSQIGP DAHMRMILKK HPSERTADDL EIIYEELLHI KALSHLSTTV
KRELAGVLIF ESHAKAGTVL FNQGEEGTSW YIILKGSVNV VIYGKGVVCT LHEGDDFGKL
ALVNDAPRAA SIVLREDNCH FLRVDKEDFN RILRDVEANT VRLKEHGLDV LVLEKSLSSS
RTSIQGSSAS HYKYKVMSGT PEKILEHLLE MMRLDSQFTE SDSALDDFVL MHCVFIPNSQ
LCPVLLAHYH AQASQGSEQE KLDYTLNNKR RVIRLVMRWA AVHGDQLQQD EVSVAFLEEF
FLAVSNDAKV LPTLRDQLIE LERTVKRNAE DARSLQKKHK ILLRQFSMGD EKLQKRQPIK
SNDEILFKVY CCDHTYTTIR VSVAASVREV IGAVADKLGS AEDLLLVNLS SAGEKSVFKP
NDVSVFSTLS INGRLFACRR DQLDSLTPLP EQEGPSTGSL TTFELMSSKD VAYHMTSYDW
ELFHCVHELE LIYHTFGRQC VKKTTVNLDL FLRRFNEIQF WVITEMCLCS QLSKRVQLLK
KFIKIAAHCK EYRNLNTFFA VIMGLSNPAV SRLTQTWEKL PSKFKKFYVE FENMMDPSRN
HRAYRLTVAK LEPPIIPFMP LLIKDMTFTH EGNKTFIDNL VNFEKMRMIA NTVKIVRYCR
SQTFSKFQFQ SFYIDVNYTV NHFKFVQHRN TSPPAS
//
