ID A0A3Q1BJ35_AMPOC Unreviewed; 253 AA.
AC A0A3Q1BJ35;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=FZ domain-containing protein {ECO:0008006|Google:ProtNLM};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000014497.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000014497.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR AlphaFoldDB; A0A3Q1BJ35; -.
DR STRING; 80972.ENSAOCP00000014497; -.
DR Ensembl; ENSAOCT00000022867.1; ENSAOCP00000014497.1; ENSAOCG00000019188.1.
DR GeneTree; ENSGT00940000164203; -.
DR OMA; WGSPGAW; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF133; SECRETED FRIZZLED-RELATED PROTEIN 5-LIKE; 1.
DR Pfam; PF01392; Fz; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT DOMAIN 1..106
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 124..251
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 4..50
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 69..93
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 253 AA; 28610 MW; B8B1C807591E750B CRC64;
MALCQNIGYD TMRMPNLLGH ESPAEAVQQS ASWLPLLARE CHPDARIFLC SLFAPICLDR
FISPCRSLCE SVRDSCAPIM SCYGYPWPEI LRCDQYPADH LMCISSITNT TVHPGGRRVP
QASCQDCELE EASSSKDTLE TFCRSDFVVK LRLTRLKYSP ASLSQFSLAA KLDVLKHGPL
LGGQIRSRIE LWLERDATCV KNMTRQHPRG GTFLVTGTVQ GEHLVVNKAY AWQRRDKDLM
AAARKWKHHR CRN
//
