ID A0A3Q1BLZ6_AMPOC Unreviewed; 923 AA.
AC A0A3Q1BLZ6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN Name=SLC4A5 {ECO:0000313|Ensembl:ENSAOCP00000015320.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000015320.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000015320.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004554}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004554}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00034693}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00034693}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR AlphaFoldDB; A0A3Q1BLZ6; -.
DR STRING; 80972.ENSAOCP00000015320; -.
DR Ensembl; ENSAOCT00000031804.1; ENSAOCP00000015320.1; ENSAOCG00000020114.1.
DR GeneTree; ENSGT00940000157488; -.
DR OMA; AIMFFCG; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR003024; Na/HCO3_transpt.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF20; ELECTROGENIC SODIUM BICARBONATE COTRANSPORTER 4; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR PRINTS; PR01232; NAHCO3TRSPRT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 381..412
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 432..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 465..488
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 563..581
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 601..619
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 649..668
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 689..713
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 749..768
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 775..794
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 826..857
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 12..260
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 318..827
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 90..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 882..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..115
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 103983 MW; 399853C7C0FE566C CRC64;
SCCRWVKFEE KVEEGGERWS KPHVSTLTLH SLFELRTCLQ TGSILLDLEG YSLPQIIVDR
QIADGLIPLD LKEKIIFVLL RKHRHQTKKP IHRSLADIGK SSNTASSNSA SGIHRSTEDL
RSRQSSSLGR LSLSFLFSVI RQLKNKFMKK IPRDAEASNV LIGEVDFLEK PFVSFVRLAQ
ATTLGGLTEV PVPTRFLFIL LGPHGKTKSY NEIGRAIATL MVDDLFSDVA YKARDREDLI
AGVDEFLDEV IVLPPGEWDP KIRIEPPKKV PSAEMRKSVL NLNELGQMNG SAGGAAGGED
EELPAPHELG EELKFTGRFC GGLWLDIKRK IPWYCSDIYD GFHIQSISAV LFIYLGCITN
AITFGGLLGD ATDNYQGVME SFLGTALAGT VFCLFGGQPL IILSSTGPIL IFEKLLYEFS
KSNNIDYMEL RLWIGLHSCL QCFLLVVSDA SYIIKYMTRF TEEGFSSLIS FIFISDAIKK
MVGAFKYYPI NRGFKPDYIT AYKCECIASD QASALNVSAP LGDDNMTLLY NLTDLDWSQL
SKKECVKYGG TLVGSSCKYV PDLALMSFIL FFGTYSMTVS LKKFKFSRYF PTKLRTLVSD
FAIIISILVF CGLDCLLELD TPKLHVPTEI KPTRIDRGWL VMPFGKNPWW WYLASFVPAL
LVTILIFMDQ QISAVIVNRK ENKLKKGCGY HLDLFWVGVL MAVCSFMGLP WYVAATVISI
AHIDSLKMES ESSAPGEQPQ FLGVREQRLT GILVFVLTGL SVFLAPVLQY IPMPVLYGVF
LYMGVASLSG IQFWERIKLY LMPSKHQPDF SFLRHVPLRR VHLFTLVQIV CLAVLWILKS
TFLAIIFPVM ILGLMVVRKL LDLMFSQHDL AWLDDILPDK DKKKKEDEKK KKKKAAEPES
DEEVRISFLG IHRVFKCVSL HLL
//
