ID A0A3Q1BNI8_AMPOC Unreviewed; 1133 AA.
AC A0A3Q1BNI8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=NLR family CARD domain containing 3 {ECO:0000313|Ensembl:ENSAOCP00000016172.1};
GN Name=NLRC3 {ECO:0000313|Ensembl:ENSAOCP00000016172.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000016172.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000016172.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR AlphaFoldDB; A0A3Q1BNI8; -.
DR Ensembl; ENSAOCT00000032181.1; ENSAOCP00000016172.1; ENSAOCG00000001550.1.
DR GeneTree; ENSGT00940000159861; -.
DR OMA; DFTQVET; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF285; NLR FAMILY CARD DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 11.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 14.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 2.
DR PROSITE; PS50209; CARD; 1.
DR PROSITE; PS50837; NACHT; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 37..116
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 214..344
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1133 AA; 124636 MW; 49DAD9FCB5BD1BA2 CRC64;
MERKTHYDSI MDRSKRITWQ DDCYVDLQST CSASSRAETE ELGWIPKHQD QLQSFITPPF
LEEILSHLTK VDVLSSAEET KIKEAGQLQD QVNMLTTIVT DKDIQGSDAL QGFIESSSSQ
VAQLIINHDS MVKQHKEVLL RRYEQYRERD SVSCPKLNIS SRTLLLVDGL SDLQQKEHDL
MQVGVTRGGK RNHLRQLGLV KLFEPLTRVS VPPRVSLTVG VAGIGKTTWV RHFIRQWSQG
AICTDVHFVL PFTFCELNSM EKLSAEKLVK MSFPHLTDPS LVLNSSCRTL IILDGLDEFR
CTLNFSDAAP CNDPKKEVSI DDLITNIIRG NLLPDVAVWV TSRPAVASLI PGGLVDRVTE
IPGFSPNEVQ IFLNHHFSER DFGSKIWAHL ESNQILMVMC YIPCICWIVA DTLLYIMQGE
TQESLPKTCT ELYAHFCSMK AELGEPRGRE PVKMEQLHGS NRKLLGNLGR LAFYGLLKHK
YTFSEQDLRA YGIDLLLTQS SLGAGVLVRE ESAIHTTYRF THLTLQEFLA ATFYHVSSKR
AIFDLFSEST MSWPKIGFQN HFRSAFQHSQ QAEDGHLDVF VRFLTGLLCP VAVKPLAGLL
AIGKDDGSQK TWAAGFLQGL LVSGGAVVSL RAVNLAYCLQ ELQHTELLRS VEDDLRLGNL
AGKLTRPHCV VLGYLLHVSP ECSNQTNLTS SLNYATVKCL LPQLLYCSHL RLENNHFKDD
VMELLGSLLS AKDCHIRKVS LAENSITNKG AKALSRALLV NRTLTSLNLR SNNIGSKGAK
FLAEALKMNQ VLISINFQNN AIEEEGAQAL ADVLQCNRKL VSLNIRKNTI GAGGAKRIAD
ALKINRTLTK LILCSNQLGD KGTVALAEAL TLNHTLLSLQ LQSNSISNRG MTALTKALRL
NRGLVSLNLR ENSIGVEGAK NMAHALHENH SLQDLDLTAN LLHDEGVQAI AGAIKFNHGL
ISLHLQWNFI KTKATKALAH ALLSNSTMQL LDLQENAIGN EGVICLAEAL KTNTCLRTLC
LQGVSAGMTG AIAMAEALTT NQTLQTLDLR GNAVGMEGAK ALANALKSNR SLKSLNLQEN
SLGMDGAIFI ATALKGNHQL TYINLQGNGI GESGAKVISD AIRASASGCV VDI
//
