ID A0A3Q1BNV4_AMPOC Unreviewed; 488 AA.
AC A0A3Q1BNV4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Transmembrane prolyl 4-hydroxylase-like {ECO:0000313|Ensembl:ENSAOCP00000014524.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000014524.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000014524.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
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DR AlphaFoldDB; A0A3Q1BNV4; -.
DR Ensembl; ENSAOCT00000031492.1; ENSAOCP00000014524.1; ENSAOCG00000019276.1.
DR GeneTree; ENSGT00390000014570; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR PANTHER; PTHR10869:SF234; ZGC:158254; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS51471; FE2OG_OXY; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 298..448
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 488 AA; 54992 MW; 76DBCA85818AF1CD CRC64;
MEDILEDLTE QEETVSDEAS SPPYNSPFRS TRLHIQRSNV CSRAYFVVVM VFFHVYILNV
IALLLYVHYN NGPGDLVSGD GLHVEDYSQS FSLPRIEGIR VGHVQQVSVV PDKTHEMRTL
SLKPLLFEIP GFLSEEECRV VVQLAQLKGL MDSQATAPSQ GQEESNQPLL SLSTDEVFSL
LDLNQDGLLQ KQEIVSHSRS RDGTWLSPDN LRQILTGLEA CPTGLWMLTL GDFRRVYDVS
QRSGEAQSGR LLSQFNQRSK HTWLHQGPGS HHVLHTLRNR SLPLLISLTR LPSALVELSE
PLQVIRYENG DFSNAHHDSS PSHSETTCAH TRLAGNTSAL TEVSCRYLTV LFYLSSVEEG
GESTFPVADN RTYEEQALVQ DGVDLTDTQE TCGRGNLRMK PTSGTALLWY NHLSDGRGWM
GELDEYSLHG DCPVRRGVKW VANSWVNVDP DHRQQARYQR LVAQRYQAKS GREDHYQSLS
HSDLHQDL
//
