ID A0A3Q1BPZ5_AMPOC Unreviewed; 583 AA.
AC A0A3Q1BPZ5;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Frizzled-8-like {ECO:0000313|Ensembl:ENSAOCP00000016395.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000016395.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000016395.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
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DR AlphaFoldDB; A0A3Q1BPZ5; -.
DR STRING; 80972.ENSAOCP00000016395; -.
DR Ensembl; ENSAOCT00000025361.1; ENSAOCP00000016395.1; ENSAOCG00000001558.1.
DR GeneTree; ENSGT00940000161191; -.
DR OMA; SWPERMA; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0060898; P:eye field cell fate commitment involved in camera-type eye formation; IEA:Ensembl.
DR GO; GO:0021879; P:forebrain neuron differentiation; IEA:Ensembl.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IEA:Ensembl.
DR GO; GO:0021531; P:spinal cord radial glial cell differentiation; IEA:Ensembl.
DR CDD; cd15250; 7tmF_FZD8; 1.
DR CDD; cd07461; CRD_FZ8; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR041776; FZ8_CRD.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF146; FRIZZLED 8A PROTEIN-RELATED; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..583
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018701703"
FT TRANSMEM 242..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 409..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 456..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 506..528
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 25..146
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 241..535
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 154..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..91
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 38..84
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 75..113
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 102..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 106..130
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 583 AA; 65696 MW; 80EF2FFACFE45D4E CRC64;
MEMDLFGIYL LLSLALLPRS SCTTAKEITC QEIAVPLCKG IGYNYTYMPN QFNHDTQDEA
GLEVHQFWPL VEIQCSPDLK FFLCSMYTPI CLEDYKKPLP PCRSVCERAR AGCAPLMRQY
GFPWPDRMKC DLLPVQGNPD TLCMDYNRTD STTVSPVLSK PTNHPGKGYN PPKNKPGRPG
APGKYKPPAA PCEPGCKCLE PMVPVNTDRH PLYNRVKTGQ ISNCAIPCHN PYFTHDERAF
TAFWIGLWSV LCFVSTFATV ATFLIDMERF KYPERPIIFL SACYMFVSIG YIVRLIAGHE
KVACNREFDL EHIHYETTGP ALCTVVFLLI YFFGMASSIW WVILSLTWFL AAGMKWGNEA
IASYSQYFHL AAWLIPSMKS IAVLALSSVD GDSVAGICYV GNQNLDNLRG FVLAPLVIYL
FIGTMFLLAG FVSLFRIRSV IKQGGTKTDK LEKLMIRIGI FTVLYTVPAT IIVACYFYEQ
HNRQSWEITH NCSNCLLERD RRVPDYAVFM LKYFMCLLVG ITSGVWIWSG KTLDSWRTFC
TRCCWGSKGT SGSMYSDVST GLTWRSGTAS SVSCPKQMPL SQV
//
