ID A0A3Q1BQW4_AMPOC Unreviewed; 765 AA.
AC A0A3Q1BQW4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Rac/Cdc42 guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSAOCP00000015948.1};
GN Name=ARHGEF6 {ECO:0000313|Ensembl:ENSAOCP00000015948.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000015948.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000015948.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, lamellipodium
CC {ECO:0000256|ARBA:ARBA00004510}.
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DR AlphaFoldDB; A0A3Q1BQW4; -.
DR Ensembl; ENSAOCT00000024768.1; ENSAOCP00000015948.1; ENSAOCG00000020888.1.
DR GeneTree; ENSGT00940000158723; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01225; PH_Cool_Pix; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd12060; SH3_alphaPIX; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.20.5.390; L1 transposable element, trimerization domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035788; AlphaPIX_SH3.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR032409; GEF6/7_CC.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR046376; PH_Cool_Pix.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46026:SF2; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR PANTHER; PTHR46026; RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F; 1.
DR Pfam; PF16523; betaPIX_CC; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF16615; RhoGEF67_u1; 1.
DR Pfam; PF16614; RhoGEF67_u2; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00033; CH; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..111
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 159..218
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 234..414
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 436..542
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 117..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 730..757
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 117..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 630..646
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 765 AA; 85533 MW; E5D6C3BABA60A649 CRC64;
MNPEEQTVTW LISLGVLSSP KKNIADPEEF LKTSLKDGVV LCKLTERLIP GFSAKYCHDP
RTEADCVSNI REFLRGCSSL KVEGFEPEWL YTGENFGKVL TTLLAVNFAT QDCAAERCPQ
SSTPSPSQTT ASHTLSSAKS KGSLRRQSKS VEMSENGGGG QLMVKARFNF KQNNEDELSF
SKGELILVTR QEEGGWWEGT LNGRTGWFPS NYVREVKPCE KPVSPKGNQL TKNYYSVVVQ
DILEHEREFV KELQTVLSCY LRPLQASDKL SSADSATLCG NLEEILAFQQ GLCSALEDCT
KVPEGQQRVA GCYLNLMCQI KTLYLAYCSS HPSAVCILTD HSEELDKFME SQGASAPGIL
TLTTSLSKPF MRLDKYPTLL QELERHVEEA HSDYIDIVKA TSAFRSLVTQ CQDLRKRKNL
ELQILSEPVR GWEGDSMKSL GHVAYMSQVH VRNGCSEEKE ERYLMLFPNV LVMLSASPRM
SGFIYQGRLP LTGTTVTRHA EDADNGHYAF DITGSMIDRI TVFCCSAQEL QEWLENLQPF
TKGGSPAGTI SKNVDGKPLS MVGTPTHLSH LGSLSAVSRC PLEQPKINKP WSLSCLRPAP
PLKPSAALGY KEDSSKSPRP MKKFLPGNRK KERKPSDDEV QTRKSTAALE EDAQILRVIE
AYCTGASLHQ TSTAVRKECV PQVLLPEEEK IIVEEMKSNG QTVIEEKSLV DAVYALKDEV
HELKKENKWM KQFLEEEQKS RKELERVVRK LAKQKNDCAW EDSSH
//
