ID A0A3Q1BRP4_AMPOC Unreviewed; 797 AA.
AC A0A3Q1BRP4;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 24-JAN-2024, entry version 24.
DE SubName: Full=Potassium voltage-gated channel subfamily Q member 2 {ECO:0000313|Ensembl:ENSAOCP00000016228.1};
GN Name=KCNQ2 {ECO:0000313|Ensembl:ENSAOCP00000016228.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000016228.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000016228.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR AlphaFoldDB; A0A3Q1BRP4; -.
DR STRING; 80972.ENSAOCP00000016228; -.
DR Ensembl; ENSAOCT00000025129.1; ENSAOCP00000016228.1; ENSAOCG00000021178.1.
DR GeneTree; ENSGT00940000160093; -.
DR OMA; TSWQPQG; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProt.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR020969; Ankyrin-G_BS.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR PANTHER; PTHR47735:SF4; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF16642; KCNQ2_u3; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01461; KCNQ2CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 88..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..142
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 228..247
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..317
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 424..607
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 422..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 556..570
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..710
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 797 AA; 88636 MW; E64C55C89526B4F1 CRC64;
MVQKSRNGGV FPGAEADQKK MKVGFVGLEA GGTESSRDGA LLIAGTQLPG RLRSSVSGGK
KPPKRNALYR RLQNFLYNVL ERPRGWAFIY HAYVFLLVFS CLVLSVFSTI REYEKSSEDA
LYILEVVTIV VFGVEYMVRI WAAGCCCRYR GWRGRLKFAR KPFCVIDIMV LIASISVLAA
GTQGNVFATS AIRSLRFLQI LRMIRMDRRG GTWKLLGSVV YAHSKELITA WYIGFLCLIL
ASFLVYLAEK EDNEQFETYA DALWWGLITL TTIGYGDKFP ITWNGRLLAA TFTLIGVSFF
ALPAGILGSG FALKVQEQHR QKHFEKRRNP AAGLIQAAWR VYATNLTRTD LTSTWDYYER
TVSVPMYRLI PPLNQLDLLR NLKNKSGLSF SLKERVFSSP RSSGTKGKGS PQHGLAGVQA
LRRSPSMEPS LEESPSKVPK SWSFGERSRT RQAFRIRGAA SRQNSEEASL PGEDMADDNK
SCHCEFVPQD LTPGLKVTIR AICIMRFMVS KRKFKESLRP YDVMDVIEQY SAGHLDMLAR
IKNLQSRVDQ IVGRGAPITD KDRPKAANEE LPEDPSMMGR LGKVEKQVLS MERKLDFLVN
IYIQRMGIPQ AETDAYFGSK EPDPAPPYHS PKTRFVTKMV RSSSSTGHRN HSAPSCPPST
SWQPISSHHG NTPSPMGDGS LVRLPPPPAG ERHGGNRSNR HREGGGEEVK PDSDASISIP
SVDHEELERS FSGFSISQSR ENLDFLNNGF YAAGSRGGGG TARCATVRPY IAEGESDSDS
ELCVPSPHSD RAWTGTK
//