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Database: UniProt
Entry: A0A3Q1BRP4_AMPOC
LinkDB: A0A3Q1BRP4_AMPOC
Original site: A0A3Q1BRP4_AMPOC 
ID   A0A3Q1BRP4_AMPOC        Unreviewed;       797 AA.
AC   A0A3Q1BRP4;
DT   10-APR-2019, integrated into UniProtKB/TrEMBL.
DT   10-APR-2019, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=Potassium voltage-gated channel subfamily Q member 2 {ECO:0000313|Ensembl:ENSAOCP00000016228.1};
GN   Name=KCNQ2 {ECO:0000313|Ensembl:ENSAOCP00000016228.1};
OS   Amphiprion ocellaris (Clown anemonefish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Pomacentridae; Amphiprion.
OX   NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000016228.1, ECO:0000313|Proteomes:UP000257160};
RN   [1] {ECO:0000313|Ensembl:ENSAOCP00000016228.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; A0A3Q1BRP4; -.
DR   STRING; 80972.ENSAOCP00000016228; -.
DR   Ensembl; ENSAOCT00000025129.1; ENSAOCP00000016228.1; ENSAOCG00000021178.1.
DR   GeneTree; ENSGT00940000160093; -.
DR   OMA; TSWQPQG; -.
DR   Proteomes; UP000257160; Unplaced.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProt.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 6.10.140.1910; -; 2.
DR   InterPro; IPR020969; Ankyrin-G_BS.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR   InterPro; IPR003947; K_chnl_volt-dep_KCNQ2.
DR   InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR   PANTHER; PTHR47735:SF4; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 2; 1.
DR   PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16642; KCNQ2_u3; 1.
DR   Pfam; PF03520; KCNQ_channel; 1.
DR   Pfam; PF11956; KCNQC3-Ank-G_bd; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01461; KCNQ2CHANNEL.
DR   PRINTS; PR01459; KCNQCHANNEL.
DR   SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT   TRANSMEM        88..108
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        120..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        228..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        288..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          91..317
FT                   /note="Ion transport"
FT                   /evidence="ECO:0000259|Pfam:PF00520"
FT   DOMAIN          424..607
FT                   /note="Potassium channel voltage dependent KCNQ C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF03520"
FT   REGION          422..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          556..577
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          638..719
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          774..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..570
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        638..674
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        694..710
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   797 AA;  88636 MW;  E64C55C89526B4F1 CRC64;
     MVQKSRNGGV FPGAEADQKK MKVGFVGLEA GGTESSRDGA LLIAGTQLPG RLRSSVSGGK
     KPPKRNALYR RLQNFLYNVL ERPRGWAFIY HAYVFLLVFS CLVLSVFSTI REYEKSSEDA
     LYILEVVTIV VFGVEYMVRI WAAGCCCRYR GWRGRLKFAR KPFCVIDIMV LIASISVLAA
     GTQGNVFATS AIRSLRFLQI LRMIRMDRRG GTWKLLGSVV YAHSKELITA WYIGFLCLIL
     ASFLVYLAEK EDNEQFETYA DALWWGLITL TTIGYGDKFP ITWNGRLLAA TFTLIGVSFF
     ALPAGILGSG FALKVQEQHR QKHFEKRRNP AAGLIQAAWR VYATNLTRTD LTSTWDYYER
     TVSVPMYRLI PPLNQLDLLR NLKNKSGLSF SLKERVFSSP RSSGTKGKGS PQHGLAGVQA
     LRRSPSMEPS LEESPSKVPK SWSFGERSRT RQAFRIRGAA SRQNSEEASL PGEDMADDNK
     SCHCEFVPQD LTPGLKVTIR AICIMRFMVS KRKFKESLRP YDVMDVIEQY SAGHLDMLAR
     IKNLQSRVDQ IVGRGAPITD KDRPKAANEE LPEDPSMMGR LGKVEKQVLS MERKLDFLVN
     IYIQRMGIPQ AETDAYFGSK EPDPAPPYHS PKTRFVTKMV RSSSSTGHRN HSAPSCPPST
     SWQPISSHHG NTPSPMGDGS LVRLPPPPAG ERHGGNRSNR HREGGGEEVK PDSDASISIP
     SVDHEELERS FSGFSISQSR ENLDFLNNGF YAAGSRGGGG TARCATVRPY IAEGESDSDS
     ELCVPSPHSD RAWTGTK
//
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