ID A0A3Q1BT68_AMPOC Unreviewed; 494 AA.
AC A0A3Q1BT68;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Fibrinogen beta chain {ECO:0000313|Ensembl:ENSAOCP00000016119.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000016119.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000016119.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Heterohexamer; disulfide linked. Contains 2 sets of 3 non-
CC identical chains (alpha, beta and gamma). The 2 heterotrimers are in
CC head to head conformation with the N-termini in a small central domain.
CC {ECO:0000256|ARBA:ARBA00025974}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; A0A3Q1BT68; -.
DR STRING; 80972.ENSAOCP00000016119; -.
DR Ensembl; ENSAOCT00000024990.1; ENSAOCP00000016119.1; ENSAOCG00000020991.1.
DR GeneTree; ENSGT00940000158122; -.
DR OMA; CIHADPD; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005577; C:fibrinogen complex; IEA:InterPro.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0072378; P:blood coagulation, fibrin clot formation; IEA:Ensembl.
DR GO; GO:0030168; P:platelet activation; IEA:InterPro.
DR GO; GO:0051258; P:protein polymerization; IEA:InterPro.
DR CDD; cd00087; FReD; 1.
DR Gene3D; 1.20.5.50; -; 2.
DR Gene3D; 3.90.215.10; Gamma Fibrinogen, chain A, domain 1; 1.
DR InterPro; IPR037579; Fibrinogen.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR014716; Fibrinogen_a/b/g_C_1.
DR InterPro; IPR002181; Fibrinogen_a/b/g_C_dom.
DR InterPro; IPR012290; Fibrinogen_a/b/g_coil_dom.
DR InterPro; IPR020837; Fibrinogen_CS.
DR PANTHER; PTHR47221; FIBRINOGEN ALPHA CHAIN; 1.
DR PANTHER; PTHR47221:SF4; FIBRINOGEN GAMMA CHAIN; 1.
DR Pfam; PF08702; Fib_alpha; 1.
DR Pfam; PF00147; Fibrinogen_C; 1.
DR SMART; SM00186; FBG; 1.
DR SMART; SM01212; Fib_alpha; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF58010; Fibrinogen coiled-coil and central regions; 1.
DR PROSITE; PS00514; FIBRINOGEN_C_1; 1.
DR PROSITE; PS51406; FIBRINOGEN_C_2; 1.
PE 4: Predicted;
KW Blood coagulation {ECO:0000256|ARBA:ARBA00023084};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hemostasis {ECO:0000256|ARBA:ARBA00022696};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 236..491
FT /note="Fibrinogen C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51406"
FT REGION 57..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 199..226
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 494 AA; 55966 MW; 64450DBC169FD764 CRC64;
MKLLNRTRCK EKPFSSNLHF LFFFSPQDAK TTDQNTTAGA NVNARGHRPL VKGREYYSRN
RNAPPPISGG SRYRGRPTSA PVGGQKVEEK VQQPEAGGCS HASEQMGVLC PTGCELKTTL
LKQEDDVKRS IRQLKPQVED LSRSSNNIFN YVNGMSITLR ERQRVFNDNN RVVGQYTDRV
EEQHAYIKET VDTVFPSNIR VLQGVLDKIK LKIQKLEKAI QAQKEECKEP CKTKCPIPVV
SGKECEDIFR RGGKDSQMYL IKPDAFSSPY KVYCDQSTLN GGWLLIQNRL DGSVDFGRRW
DEYRRGFGNI AFDAGKGHCE TPGEYWLGND RISQVTKMGP TEVLIEMQDW TGAKVQAQYR
QFTIQSETSN YVLAVDGYSG NAGNGFLEGS LELFGENRTM TIHNGMMFST YDRDNDNWNP
GDPSKQCARE DGGGWWYNRC HSANPNGRYY IGGAYTKQMA KHGTDDGVVW MNWKGSWYSL
KAISMKIRPF FASR
//
