ID A0A3Q1BVD6_AMPOC Unreviewed; 825 AA.
AC A0A3Q1BVD6;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=LDL receptor related protein 3 {ECO:0000313|Ensembl:ENSAOCP00000017558.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000017558.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000017558.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane, coated pit
CC {ECO:0000256|ARBA:ARBA00037878}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR AlphaFoldDB; A0A3Q1BVD6; -.
DR Ensembl; ENSAOCT00000026899.1; ENSAOCP00000017558.1; ENSAOCG00000022647.1.
DR GeneTree; ENSGT00940000160021; -.
DR OMA; NFDLMES; -.
DR OrthoDB; 2916406at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 4.10.1220.10; EGF-type module; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 4.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24270; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED; 1.
DR PANTHER; PTHR24270:SF22; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 3; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 3.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|ARBA:ARBA00023176};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..825
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5018669876"
FT DOMAIN 25..138
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 233..345
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 650..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 678..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..792
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 145..157
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 152..170
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 164..179
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 213..228
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 368..383
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 407..422
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 425..437
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 432..450
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 444..459
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 825 AA; 89765 MW; F430B53CDA0C14D3 CRC64;
MRLLLLLLLL LLLLLRAATL CAAGCSEQVE VHTERRGVIY SPSWPLNYPS GVNCSWHIQG
GQGEVITISF RNFDVADSGR CLGDWLLLTP TWSGESRLCG SVLPPPFIST RGRVWLYFHS
QANSSGQAQG FRLSYIRGHL GQSSCQSDEF LCGNGKCLPR SWKCNGQDEC GDATDERSCS
PPPTEAQPGL CPFGSVPCTE AQSTRCLPAA LRCNGARDCR DGTDELGCPD TTCGKRLGNF
YGAFASPDFF RANRSAVTEL RCSWLLDTQD PKPIMLQLDL QLGPGDSLHV YDGLMQRAEH
LLQVLSYHNN RRPALLESSR GQMSVLYVAQ PHSPGHGFNA TYQVKGYCFP GERPCGSDQG
CFSERQRCDG YWHCPSGRDE ESCPMCPDGE FPCEGGTGVC YPASERCNNQ KRCPDGSDEK
NCYDCQPGNF HCGTNLCIFE TWRCDGQEDC LDGSDERDCL AAVPRKVITA ALIGSLVCSL
LLVIALGCAL KLHSLRSREY RAFETQMTRM EAEFVQREAP PSYGQLIAQG LIPPVEDFPV
YNPTQVSVLQ NLRLAMRRQI RRHSTRRSTS SSSRRRLGHL WTRLFQTGGR ARGQAPLLDP
PGPTQITLGL HSYRTAGEQG PHDGAVSGGG LRDEAGALGS CCSATVDLEP CTPESPASPL
SFHSVDSPDE EELSPFSRES SGAPQSGPPT PCQSDSSSHS GLPPTPQEAS VPLCPRRASR
KMVLELAVNL KGVSLRRYSP LGPLSPISPP VFPSSSQTPS TQPHPQGSEV TSPTGPLSSS
VKAEGSDSNS TVDVPSRDER KREENIRLSR TLSDEGGDSG WETPR
//
