ID A0A3Q1BW97_AMPOC Unreviewed; 438 AA.
AC A0A3Q1BW97;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Ammonium transporter Rh type A {ECO:0000256|ARBA:ARBA00041037};
DE AltName: Full=Erythrocyte membrane glycoprotein Rh50 {ECO:0000256|ARBA:ARBA00042473};
DE AltName: Full=Rhesus blood group family type A glycoprotein {ECO:0000256|ARBA:ARBA00042104};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000018660.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000018660.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an ammonia transporter. May play a role in the
CC elimination of ammonia in the gill. {ECO:0000256|ARBA:ARBA00025220}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=CO2(out) = CO2(in); Xref=Rhea:RHEA:74891, ChEBI:CHEBI:16526;
CC Evidence={ECO:0000256|ARBA:ARBA00035761};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=NH4(+)(in) = NH4(+)(out); Xref=Rhea:RHEA:28747,
CC ChEBI:CHEBI:28938; Evidence={ECO:0000256|ARBA:ARBA00000309};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=methylamine(out) = methylamine(in); Xref=Rhea:RHEA:74391,
CC ChEBI:CHEBI:59338; Evidence={ECO:0000256|ARBA:ARBA00036281};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ammonium transporter (TC 2.A.49) family. Rh
CC subfamily. {ECO:0000256|ARBA:ARBA00011036}.
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DR AlphaFoldDB; A0A3Q1BW97; -.
DR STRING; 80972.ENSAOCP00000018660; -.
DR Ensembl; ENSAOCT00000033230.1; ENSAOCP00000018660.1; ENSAOCG00000023842.1.
DR GeneTree; ENSGT00950000182844; -.
DR OMA; CYEMEDG; -.
DR OrthoDB; 5483564at2759; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008519; F:ammonium transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.10.3430.10; Ammonium transporter AmtB like domains; 1.
DR InterPro; IPR029020; Ammonium/urea_transptr.
DR InterPro; IPR024041; NH4_transpt_AmtB-like_dom.
DR InterPro; IPR002229; RhesusRHD.
DR PANTHER; PTHR11730; AMMONIUM TRANSPORTER; 1.
DR PANTHER; PTHR11730:SF32; AMMONIUM TRANSPORTER RH TYPE A; 1.
DR Pfam; PF00909; Ammonium_transp; 1.
DR PRINTS; PR00342; RHESUSRHD.
DR SUPFAM; SSF111352; Ammonium transporter; 1.
PE 3: Inferred from homology;
KW Ammonia transport {ECO:0000256|ARBA:ARBA00023177};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000257160};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..31
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 62..81
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..169
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 243..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..323
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 372..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 57..410
FT /note="Ammonium transporter AmtB-like"
FT /evidence="ECO:0000259|Pfam:PF00909"
FT REGION 416..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 47111 MW; 85F56038E8ABCE2E CRC64;
MPAYATNMRL KFPILALILE IITIILFAVF VDYDDGKGHG HDSHSNSSET HHEEKPMDLY
PMFQDVHVMI FIGFGFLMTF LKRYGFSSVG INLLLAAFGL QWGLLMQGVW HLVDGKIKIN
IFKIINADFS TATVLISFGA VLGKTSPVQL LIMTILEITI FSINEHLVAT VLEANDVGAS
MIIHAYGAYF GLAVARVLYR PGLRNGHENE GSVYHSDLFA MIGTVFLWMF WPSFNSAIAD
PGLTQLTAVI NTYLSLAACV LSAYAISSLV EHKGKLDMVH IQNATLAGGV AVGTCADMNI
GPFGAMLIGL VAGIISTLGF KFLSPILASS VGIQDTCGVH NLHGMPGILG GLAGIVAVSL
GKKEGGDPVM QAAALASSLG FALVGGAVTG FIMKLPFWGQ PPDQNCYDDS LYWEVPEEED
ENEESLAHAD HSKNKAEV
//
