ID A0A3Q1BWF8_AMPOC Unreviewed; 1576 AA.
AC A0A3Q1BWF8;
DT 10-APR-2019, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Pleckstrin homology and RhoGEF domain containing G4B {ECO:0000313|Ensembl:ENSAOCP00000018725.1};
GN Name=PLEKHG4B {ECO:0000313|Ensembl:ENSAOCP00000018725.1};
OS Amphiprion ocellaris (Clown anemonefish).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Pomacentridae; Amphiprion.
OX NCBI_TaxID=80972 {ECO:0000313|Ensembl:ENSAOCP00000018725.1, ECO:0000313|Proteomes:UP000257160};
RN [1] {ECO:0000313|Ensembl:ENSAOCP00000018725.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSAOCT00000028372.1; ENSAOCP00000018738.1; ENSAOCG00000023913.1.
DR Ensembl; ENSAOCT00000033255.1; ENSAOCP00000018725.1; ENSAOCG00000023913.1.
DR GeneTree; ENSGT00940000162507; -.
DR OMA; DLWLQCP; -.
DR Proteomes; UP000257160; Unplaced.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd13242; PH_puratrophin-1; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR45845:SF1; PLECKSTRIN HOMOLOGY AND RHOGEF DOMAIN CONTAINING G4B; 1.
DR PANTHER; PTHR45845; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000257160}.
FT DOMAIN 1048..1225
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1237..1344
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 71..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 190..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 320..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1049
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1472..1502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..286
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 320..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..872
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 887..936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1049
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1477..1502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1576 AA; 176634 MW; 7DEE3502F2AD4385 CRC64;
MYGSVFTAEF LQNVTRDRNL HPLQNCLLTT GTAVYRTPWK NVVNPLFVSS TADAIMQARC
SRGGFRGHLS TCSTSGSTGT LDSHRSSRES LHSQGADSIF SEPTTPNRNH TDSSSENHAD
PAAPIVKIER PAEECGVGQD GGGRDRGSKM LSFSTDLSNP GPRRRLPRDS AAFESRRLFR
KSYMEALQNP MSLGSSSESI LEESPEHSAG LRQGTVTPGS SPDTRTSPRE HLSRRFGSRG
WLSGDDSRPS TPLLYFQRGL RSAERRAERR SKSLERTNKA GQVKGHRERS SSGGSTSISP
KKLINGYALR FGKLDVEAAL PGTERRSSKE ETGQREDSIS TENRRHRNSG EELHSPKAAN
GTAIRHECNA VFPKLVSEVN QELLTSGAVI LPGNRDRGGR AVLQVCTRAQ VWAGESSTAD
DLTCLLGYYC STLRKERRDQ GLTVVIDSRR QQPVPALLSS LSEFQALVPN ALYSVLFLVD
KEAAAKPERD ISVQTETLSS LKALLKHIDQ TQLTRELEGT FHYDHNHWIH FRQKIEPFAS
SCSAAITSLQ ESISTLSASS NLKTSKEVSE AIEQQRHLMK CVLDDTRLNR LRLEGGTVLA
RIRKEEACEN ENYRDAVDML NALYNQVDEE VHKLVILSNK SQKQLESLLE VRKFEEQTQQ
IKLWFSVAGE KQLTPLESPT LSAAKIKEMR ESLDQFLEES VQQQRLGLQL VKESPESLPG
SVLLDFKQHL GSVLSRVEQR KTKLDILTNL YEFYDSANQW MDHCQDYFRH LNLENTAGRF
SPSVVQILQD YCNEASKFSM DNFSMLNSMV LSLESPQQLQ QWNSVWHKCQ QTKQQLEETL
ARSTTAEPNS TSADESDVLK TPESQTVSPE QRGANRCVRL PVSITPLTFE DSKNDSPVPF
SKSPTSSISS TSHFTFSPDS ESKLRQSPSM FDDTDSDCTV DSTISCHSEP IYSGASRLRK
QPMKKIMKKT MSYELTPRDS GHSDVSHVHG YTGVYIKGLE VANNVSAEKK LQRPDVMSPA
LGRSRSMSTP SRTHNRRSDG EGKKQSSKVQ HIMDEMISTE REYVRSLSYI IEHYFPEMER
LDLPQDLRGK RSIIFGNVEK LWDFHSQYFL KELEACAHSP LSISSCFLRH EDQFGMYALY
SKNKPQSDAL LCSHGNEFFK NKQMELGDKM DLASYLLKPI QRMSKYALLL KDLIKECSQS
QEQELNDLRT AEEMVKFQLR HGNDLLAMDA IRGCDVNLKE QGQLRCQDEF IVWCGRRKYL
RHVFLFEDLI LFSKTKKIEG GYDIYIYKQS FKTAEIGMTE NVGDSGLRFE IWFRRRKSQD
TFILQASSAE VKAVWTAIIG KILWRQALRN RELRMQEMVS MGIGSKPFMD IKPSDAAISD
RAIDYIMKGT ESRTRASIAV PSFEHCTSFK RPHSTISNSS TSSSSSQSSS SLLGSLNLHL
YSSPSHPHTH PYPLGSVSSF AQWPYDCIEE DELEQETGSQ PSMITESSET SSPCTSSDSV
TGLSTLTIPG HTAISMDAYN NNNNSEPSSF LCSSTPPSSI TSPSIFQKDE DLQPPGTKFI
TASKTSHIAV GLSTVV
//
